Clinical Trials in Los Angeles

Showing 2761-2780 of 16,901 trials

Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia

NCT05445323

This is a Phase 1/2, open-label, dose-ascending, multicenter study of the safety and efficacy of LX2006 for participants who have Friedreich's Ataxia with evidence of cardiomyopathy. The study will evaluate up to three doses of single administration of LX2006 (AAVrh.10hFXN), an adeno-associated virus (AAV) gene therapy designed to intravenously deliver the human frataxin (hFXN) gene to cardiac cells over a 52-week period. Long-term safety and efficacy will be evaluated for an additional 4-years for a total of 5-years post LX2006 treatment.

Friedreich AtaxiaCardiomyopathy, Secondary

Lexeo Therapeutics8 participantsStarted Aug 2022

Los Angeles, California, United States • Tampa, Florida, United States • Rochester, Minnesota, United States

COMPLETEDPhase 3< 1 mile

Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients

NCT04578834

The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of iptacopan (LNP023) at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.

IgA Nephropathy

Novartis Pharmaceuticals518 participantsStarted Jan 2021

Glendale, Arizona, United States • Phoenix, Arizona, United States • Los Angeles, California, United States +174 more locations

Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia

Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients

Find Trials by Condition in Los Angeles

Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia A

Safety and Efficacy of Nonacog Beta Pegol (N9-GP) in Previously Untreated Patients With Haemophilia B

SP Thoracic IDE Study

A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa

Diagnosing Clinically Significant Prostate Cancer In African American and White Men With Elevated PSA

The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY)

Study of Seladelpar in Participants With Primary Biliary Cholangitis (PBC)

A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

Oncolytic Adenovirus TILT-123 With Pembrolizumab as Treatment for Refractory Non-Small Cell Lung Cancer

HIV Provider Intervention to Address Intersectional Stigma and Medical Mistrust

Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV

Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy