Clinical Trials in Illinois

Showing 5621-5640 of 14,943 trials

Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

NCT03734588

SPK-8016 is in development for the treatment of patients with inhibitors to FVIII. This Phase 1/2, open-label, non-randomized, dose-finding study to evaluate the safety, efficacy, and tolerability of SPK-8016 in adult males with severe hemophilia A and no measurable inhibitor against FVIII.

Adeno-Associated Virus (AAV)Blood Coagulation DisorderBlood Coagulation Disorders, Inherited+14 more

Spark Therapeutics, Inc.4 participantsStarted Jan 2019

Los Angeles, California, United States • Peoria, Illinois, United States • Ann Arbor, Michigan, United States +8 more locations

COMPLETEDNA44 miles

Acute Cognition and Exercise

NCT05078203

The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims: Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity. Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity. Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.

Obesity

University of Illinois at Urbana-Champaign26 participantsStarted Sep 2021

Urbana, Illinois, United States

Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

Acute Cognition and Exercise

Find Trials by Condition in Illinois

Reducing Opioid Mortality in Illinois

Prevalence of PD-L1 Expression in Patients With Advanced Urothelial Carcinoma

Pilot Immunotherapy Study With Letetresgene Autoleucel (Lete-cel, GSK3377794)T-cells in New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1)/ LAGE-1a-positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab

Afimoxifene in Reducing the Risk of Breast Cancer in Women With Mammographically Dense Breast

A Study to Compare Bempegaldesleukin (BEMPEG: NKTR-214) Combined With Nivolumab and Tyrosine Kinase Inhibitor (TKI) to Nivolumab and TKI Alone in Participants With Previously Untreated Kidney Cancer That is Advanced or Has Spread

Efficacy & Safety Evaluation of Enobosarm in Combo With Abemaciclib in Treatment of ER+HER2- Metastatic Breast Cancer

Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool

A Study of LY3471851 in Participants With Psoriasis

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis

Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM

Safety and Efficacy Comparison of Docetaxel and Ixabepilone in Non Metastatic Poor Prognosis Breast Cancer

Phase 3 Study of SNF472 for Calciphylaxis

Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study

Gene Therapy With hLB-001 in Pediatric Patients With Severe Methylmalonic Acidemia

Pilot Prospective Study: Long-term Health of Living Kidney Donors

Nivolumab Ipilimumab in Patients With hyperMutated Cancers Detected in Blood (NIMBLe)

COMbination of Bipolar Androgen Therapy and Nivolumab

A Prospective, Global, Multi-center, Treatment Registry Study of Intravenous Immunoglobulin Maintenance Therapy in Alloantibody Positive Renal Allograft Recipients