Clinical Trials in Illinois

Showing 2781-2800 of 9,411 trials

Evaluation of Lasofoxifene Combined With Abemaciclib in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

NCT04432454

This is an open-label, multicenter, single-arm safety study evaluating the safety and tolerability of the lasofoxifene and abemaciclib combination for the treatment of pre- and postmenopausal women with locally advanced or metastatic ER+/HER2- breast cancer who have disease progression on first and/or 2nd lines of hormonal treatment for metastatic disease and have an ESR1 mutation.

Metastatic Breast Cancer

Sermonix Pharmaceuticals Inc.29 participantsStarted Sep 2020

Birmingham, Alabama, United States • Yuma, Arizona, United States • Fountain Valley, California, United States +13 more locations

COMPLETEDPhase 3108 miles

Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast Cancer Which Progressed on or After Aromatase Inhibitor Treatment.

NCT02437318

To determine whether treatment with alpelisib plus fulvestrant prolonged progression-free survival (PFS) compared to fulvestrant and placebo in men and postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor-2 (HER2)-negative advanced breast cancer, who received prior treatment with an aromatase Inhibitor (AI) either as (neo)adjuvant or for advanced disease.

Breast Cancer

Novartis Pharmaceuticals572 participantsStarted Jul 2015

Chandler, Arizona, United States • Scottsdale, Arizona, United States • Fayetteville, Arkansas, United States +194 more locations

Evaluation of Lasofoxifene Combined With Abemaciclib in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast Cancer Which Progressed on or After Aromatase Inhibitor Treatment.

Find Trials by Condition in Illinois

ATHN 7: Hemophilia Natural History Study

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer

Myeloma-Developing Regimens Using Genomics (MyDRUG)

A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies

Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration

Alcoholic Hepatitis Network Observational Study

A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease

Futibatinib Versus Gemcitabine-Cisplatin Chemotherapy as First-Line Treatment of Patients With Advanced Cholangiocarcinoma Harboring FGFR2 Gene Rearrangements

TAC T-cells for the Treatment of Claudin 18.2 Positive Solid Tumors (TACTIC-3)

Surveillance and Alert-based Multiparameter Monitoring to Reduce Worsening Heart Failure Events

Open-Label Study of Setmelanotide in Hypothalamic Obesity

A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome

Non-comparative Study of IFX-1 Alone or IFX-1+Pembrolizumab in Patients With Locally Advanced or Metastatic cSCC.

Artoss Prospective Spine Registry Outcomes

Psychological Response and Readiness Associated With OCD of the Knee

A Follow up Study of Patients Treated With Imlifidase Prior to Kidney Transplantation