Clinical Trials in Houston

Showing 161-180 of 15,366 trials

DFT383 in Pediatric Participants With Nephropathic Cystinosis

NCT06910813

An open-label, multi-center, phase I/II study to assess the safety, tolerability and efficacy of DFT383 in pediatric participants with nephropathic cystinosis, followed by a long-term extension phase. The purpose of this clinical study is to assess safety, tolerability, and efficacy of DFT383 in participants aged 2 to 5 years with nephropathic cystinosis. The study consists of a Core Phase and a long-term Extension Phase. DFT383 is a cellular gene therapy. This study includes an active arm (Cohort 1) of participants treated with study treatment DFT383 and a concurrent reference arm (Cohort 0). Participants in Cohort 0 will not receive study treatment and will only participate in the Core Phase of the study. The study is not randomized and Cohort 0 aims to collect prospective and concurrent data in this rare disease.

Nephropathic Cystinosis

Novartis Pharmaceuticals30 participantsStarted Jun 2025

San Diego, California, United States • Stanford, California, United States • Atlanta, Georgia, United States +1 more locations

Active Not RecruitingPhase 1< 1 mile

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

NCT04960579

Phase 1 study comprised of open-label, dose escalation, multiple cohorts of P-BCMA-ALLO1 allogeneic T stem cell memory (Tscm) CAR-T cells in subjects with relapsed / refractory Multiple Myeloma (RRMM).

Multiple Myeloma

Poseida Therapeutics, Inc.275 participantsStarted May 2022

Goodyear, Arizona, United States • San Diego, California, United States • San Francisco, California, United States +20 more locations

DFT383 in Pediatric Participants With Nephropathic Cystinosis

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

Find Trials by Condition in Houston

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

Phase 2 Study Of Imetelstat for Patient With Myelodysplastic/Myeloproliferative Neoplasms

Can the Language Environment Analysis Start Program Improve Children's Readiness for School? LENA Program Evaluation

Safety and Efficacy Study of VIS649 for IgA Nephropathy

A Study of SmartFlow Magnetic Resonance (MR) Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Participants

Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity

Varenicline and Combined NRT for Smoking Cessation

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer

Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis

A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis

Detection and Risk Stratification in Veterans Presenting With Microscopic Hematuria

Efficacy and Utility of Cxbladder Tests in Hematuria Patients

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer