Clinical Trials in Houston

Showing 7561-7580 of 17,885 trials

SAR439459 and Cemiplimab for the Treatment of Advanced or Unresectable Solid Tumors, Strategic Alliance, TACTIC TRIAL

NCT04729725

This is a phase Ib trial with SAR439459, a TGF-beta inhibitor, in combination with cemiplimab, a PD-L1 inhibitor, in patients with solid tumors that have spread to other places in the body (advanced) or cannot be removed by surgery (unresectable). Inhibiting TGF-beta may interfere with the ability of cancer cells to grow and spread and may sensitize cancers to immune checkpoint inhibitor therapy. The objective of this study is to determine whether this drug combination is effective in shrinking cancers, keeping them from growing, helping patients live longer, and to see if the drug combination is safe.

Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm

M.D. Anderson Cancer Center3 participantsStarted Feb 2021

Houston, Texas, United States

COMPLETEDPhase 4< 1 mile

Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)

NCT01770145

This study is designed to assess the effect of APOKYN treatment in rapid and reliable improvement of motor symptoms in Parkinson's disease (PD) subjects suffering from delayed or unreliable onset of levodopa (L-dopa) action.

Parkinson's DiseaseMotor SymptomsAkinesia+2 more

MDD US Operations, LLC a subsidiary of Supernus Pharmaceuticals127 participantsStarted Dec 2012

Los Angeles, California, United States • Reseda, California, United States • Washington D.C., District of Columbia, United States +9 more locations

SAR439459 and Cemiplimab for the Treatment of Advanced or Unresectable Solid Tumors, Strategic Alliance, TACTIC TRIAL

Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)

Find Trials by Condition in Houston

A Study of Tucatinib vs. Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer

Marfan Syndrome Moderate Exercise Pilot

Aromatherapy Protocol for Pain Reduction in Hospice Patients

SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain

ADVM-022 Intravitreal Gene Therapy for Wet AMD

Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)

A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma

A Study to Examine Past Estimated Glomerular Filtration Rate (eGFR) Slope as a Risk Marker for Rapid Kidney Function Decline in People With Chronic Kidney Disease

A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy

Prospective Group-Matched Study With Belzupacap Sarotalocan (Bel-sar; AU-011) or Plaque Radiotherapy for Primary Indeterminate Lesions or Choroidal Melanoma (IL/ CM)

Safety and Immunogenicity of AdCOVID in Healthy Adults (COVID-19 Vaccine Study)

A Safety, Efficacy and Systemic Exposure Study of CD5789 Cream in Adults and Adolescents With Lamellar Ichthyosis

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

Study of OT-101 in Treating Myopia

A Study to Evaluate Safety and Immunogenicity of One or Two Booster Vaccinations With H5N6 Influenza Vaccine in Adults Primed With H5N1 Influenza Vaccine or Unprimed

Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain

A Study of Adavosertib as Treatment for Uterine Serous Carcinoma

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of MTPS9579A in Patients With Asthma Requiring Inhaled Corticosteroids and a Second Controller