Clinical Trials in Houston

Showing 5161-5180 of 17,885 trials

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

NCT05840510

This study will evaluate the safety, MTD and/or RP2D, PK, and clinical activity of the combination of adagrasib with nab-sirolimus in patients with advanced solid tumors/NSCLC with a KRAS G12C mutation.

Solid Tumor, AdultNSCLCAdvanced Cancer+2 more

Mirati Therapeutics Inc.6 participantsStarted Aug 2023

Cleveland, Ohio, United States • Nashville, Tennessee, United States • Houston, Texas, United States

COMPLETEDPhase 1< 1 mile

CLN-418 Study on Subjects With Advanced Solid Tumors

NCT05306444

Study to evaluate the safety and tolerability of the study drug CLN-418, to determine the maximum tolerated dose and/or recommended Phase 2 study dose of CLN-418.

Advanced Solid Tumor

Harbour BioMed US, Inc.48 participantsStarted May 2022

Los Angeles, California, United States • Sarasota, Florida, United States • Huntersville, North Carolina, United States +4 more locations

Active Not RecruitingNA< 1 mile

Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing

NCT06805877

Scale-up of HIV preexposure prophylaxis (PrEP) is a key strategy of the U.S. initiative to end the HIV epidemic, but healthcare providers lack tools to support PrEP discussions and prescribing for patients likely to benefit. This research will evaluate whether integrating automated tools into electronic health records to help providers efficiently and equitably identify potential candidates for PrEP, discuss PrEP, and prescribe PrEP can improve PrEP initiation and persistence in safety-net community health centers. It will achieve this by conducting a stepped-wedge trial of a decision support tool with an embedded HIV prediction model to identify patients likely to benefit from PrEP. The intervention will be delivered to healthcare providers in 16 community health centers within the national OCHIN network.

HIV

Harvard Pilgrim Health Care16 participantsStarted Apr 2025

Fremont, California, United States • Oakland, California, United States • Oceanside, California, United States +13 more locations

Adagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)

CLN-418 Study on Subjects With Advanced Solid Tumors

Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing

Find Trials by Condition in Houston

Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency

A Trial of Setanaxib in Patients With Primary Biliary Cholangitis (PBC) and Liver Stiffness

Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System

Study of REM-422 in Patients With AML or Higher Risk MDS

Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System

HiLo: Pragmatic Trial of Higher vs Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis

Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

DALY II USA/ MB-CART2019.1 for DLBCL

Burn Validation Study

Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA

User Acceptability Evaluation of Pseudophakic Patients Previously Implanted With the TECNIS Odyssey IOL

Comparative Study of Conventional MR Images With Synthetically Reconstructed MR Images of the Brain