Clinical Trials in Detroit

Showing 12061-12080 of 19,719 trials

A Study Evaluating the Safety of Escalating Doses of DLYE5953A in Patients With Refractory Solid Tumors

NCT02092792

This is an open-label, multicenter, Phase I study to evaluate the safety, tolerability, and PK of escalating doses of DLYE5953A administered to patients with incurable, locally advanced, or metastatic solid malignancy that has progressed on standard therapy. The Phase I study consists of two stages: Stage 1 dose-escalation and Stage 2 expansion in selected patients. In Stage 1, a 3 + 3 dose-escalation design will be used to examine the safety, tolerability, and PK of increasing doses of DLYE5953A. In Stage 2, patients will be enrolled to further characterize the safety, tolerability, and PK of the proposed dose and schedule for future studies.

Neoplasms

Genentech, Inc.42 participantsStarted Apr 2014

Aurora, Colorado, United States • New Haven, Connecticut, United States • Boston, Massachusetts, United States +2 more locations

COMPLETEDPhase 3< 1 mile

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy

NCT02384941

This Phase 3 study was intended to demonstrate superiority of either sotagliflozin high dose or low dose versus placebo on glycosylated hemoglobin A1C (A1C) reduction at Week 24 when used as an adjunct in adult participants with type 1 diabetes mellitus (T1D) who have inadequate glycemic control with insulin therapy.

Type 1 Diabetes Mellitus

Lexicon Pharmaceuticals793 participantsStarted Mar 2015

Birmingham, Alabama, United States • Little Rock, Arkansas, United States • Escondido, California, United States +72 more locations

A Study Evaluating the Safety of Escalating Doses of DLYE5953A in Patients With Refractory Solid Tumors

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy

Find Trials by Condition in Detroit

Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer.

Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)

A Study to Evaluate Safety and Exploratory Efficacy of KTP-001 in Subjects With Lumbar Disc Herniation

Study of the Effectiveness of Green Diode Laser Light on Body Shaping

Study of the Combined Effect of Low Level Laser Therapy and Manual Lymph Drainage on Reducing Body Circumference

Study of Low Level Laser Therapy for Body Contouring

Paired Analysis of Sensitivity for Colorectal Cancer Using COLVERA : PASCAL

A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study)

Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction

Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer

Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma

Sanofi Pasteur Quadrivalent Influenza Vaccine (QIV) Pregnancy Registry

Dose-ranging Study in Patients With Type 1 Diabetes Mellitus

Direct Oral Anticoagulant Assay Detection & Classification Study for the TEG 6S System

Imatinib Treatment in Recent Onset Type 1 Diabetes Mellitus

Assessment of Ventilatory Management During General Anesthesia for Robotic Surgery

Neocate In Infants and Children With Complex Conditions

A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State