Clinical Trials in Detroit

Showing 11901-11920 of 16,931 trials

Safety, Preliminary Efficacy and Pharmacokinetics of ASN001 in Metastatic Castrate Resistant Prostate Cancer

NCT02349139

This study will be conducted in three parts. Part A is a dose-escalation study to determine two safe and tolerable doses of ASN001 for men with metastatic castration resistant prostate cancer. Part A will also characterize the pharmacokinetics and pharmacodynamics of the ASN001 through blood sampling. Subjects in Part B will receive one of two doses identified in Part A to determine which one is more effective, and collect additional pharmacokinetic data. Part C is an extension for subjects completing either Part A or B.

Cancer of the ProstateNeoplasms, ProstateProstate Cancer+3 more

Asana BioSciences27 participantsStarted Jan 2015

Los Angeles, California, United States • Detroit, Michigan, United States • Cleveland, Ohio, United States +3 more locations

COMPLETEDPhase 1/2< 1 mile

Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

NCT00305864

This phase I/II trial is studying the side effects and best dose of motexafin gadolinium when given together with temozolomide and radiation therapy and to see how well they work in treating patients with newly diagnosed supratentorial glioblastoma multiforme or gliosarcoma. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Motexafin gadolinium may help temozolomide work better by making tumor cells more sensitive to the drug. Radiation therapy uses high-energy x-rays to kill tumor cells. Motexafin gadolinium may also make tumor cells more sensitive to radiation therapy. Giving motexafin gadolinium together with temozolomide and radition therapy may kill more tumor cells.

Adult Giant Cell GlioblastomaAdult GlioblastomaAdult Gliosarcoma

National Cancer Institute (NCI)118 participantsStarted Feb 2006

Mobile, Alabama, United States • Scottsdale, Arizona, United States • Tucson, Arizona, United States +103 more locations

Safety, Preliminary Efficacy and Pharmacokinetics of ASN001 in Metastatic Castrate Resistant Prostate Cancer

Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

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Third International Study on Mechanical Ventilation

Continuation Study of Lapatinib Monotherapy or Lapatinib in Combination With Other Anti-cancer Agents

Deflazacort Expanded Access Program for Children, Adolescents and Adults With Duchenne Muscular Dystrophy

Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals?

Augmenting Balance in Individuals With Cerebellar Ataxias

Impact of Physical Activity for Chronic Pelvic Pain

Study of Efficacy and Safety of Sunitinib Given on an Individualized Schedule

Patient Real-world Clinical, Neurological, Tolerability, and Safety Outcomes for Tecfidera® and Rebif®

Efficacy, Safety, and Pharmacokinetics (PK) Study of Ulimorelin in Patients With Enteral Feeding Intolerance (EFI): The PROMOTE Trial

Long-term Follow-up of Participants From Studies Evaluating GSK HIV Vaccine

The Captivator EMR Registry

A Phase 1 Study Evaluating CB-5083 in Subjects With Lymphoid Hematological Malignancies

Cardiovascular Improvements With MV ASV Therapy in Heart Failure

Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder

Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac Diseases

Study of Carfilzomib for Multiple Myeloma Patients Who Are Relapsed/Refractory to Bortezomib-containing Treatments

Investigating the Effect of Vortioxetine in Adult ADHD Patients

Phase I Dose Escalation and Expansion of Oral BAY 1143269 in Combination With Intravenous Docetaxel