Clinical Trials in Detroit

Showing 10981-11000 of 16,931 trials

Study of RXDX-105, Potent RET Inhibitor in Patients With Advanced Lung Cancer and Other Solid Tumors

NCT01877811

This is a first-in-human, multicenter, open-label study consisting of 2 phases. Phase 1 is a dose escalation study of RXDX-105 (formerly known as CEP-32496) in patients with advanced solid tumors aimed at defining the recommended Phase 2 dose (RP2D) and schedule for administration. Phase 1b is a dose expansion in approximately 90 patients with advanced solid tumors with specific histologies and/or molecular alterations of interest. Patients in Phase 1b will be treated at the RP2D determined in Phase 1.

Solid Tumors

Hoffmann-La Roche143 participantsStarted Jun 2013

Duarte, California, United States • Irvine, California, United States • San Diego, California, United States +11 more locations

TERMINATEDPhase 2< 1 mile

Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)

NCT01467076

This is a randomized controlled trial (RCT) on the use of Inhaled prostaglandin E1 (IPGE1) in Neonatal Hypoxemic Respiratory Failure (NHRF). Fifty patients recruited at 10 high volume sites within the NICHD Neonatal Research Network will constitute a pilot sample to evaluate the feasibility and safety of prolonged IPGE1 administration and determination of optimal dose. In this Pilot RCT, two doses of IPGE1 (300 and 150 ng/kg/min) will be administered over a maximum duration of 72 hours and compared with placebo. Once feasibility and safety of IPGE1 administered over 72 hours has been demonstrated in the pilot trial, a full scale randomized controlled trial will be planned.

PrematurityRespiratory InsufficiencyPulmonary Hypertension+1 more

NICHD Neonatal Research Network7 participantsStarted Nov 2011

Birmingham, Alabama, United States • Los Angeles, California, United States • Palo Alto, California, United States +8 more locations

Study of RXDX-105, Potent RET Inhibitor in Patients With Advanced Lung Cancer and Other Solid Tumors

Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)

Find Trials by Condition in Detroit

Study to Understand Pain Experiences in Relationships

Safety and Efficacy Evaluation of DOTAREM® in MRI of Central Nervous System (CNS) Lesions

Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy

A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.

Brain Computer Interface for Communication in Ventilated Patients

ARMS-I (a Formulation of Cetylpyridinium Chloride -CPC)

10003 PRO Current Products

Safety and Tolerability of PF-05230907 in Intracerebral Hemorrhage

A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion

Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

A Study Evaluating the Efficacy and Safety of BOTOX® or Solifenacin in Patients With Overactive Bladder and Urinary Incontinence

Assessment of nanOss Bioactive 3D in the Posterolateral Spine

Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta

Sym004 vs Standard of Care in Subjects With Metastatic Colorectal Cancer

A Randomized Trial of Effects of Parent Mentors on Insuring Minority Children

Safety and Efficacy of Entospletinib (ENTO [GS-9973]) Combined With Vincristine (VCR) in Adult Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (NHL)

Safety and Efficacy Study of Dexamethasone Versus Ranibizumab in Patients With Diabetic Macular Edema

Evaluation of AGN-150998 in Exudative Age-related Macular Degeneration (AMD)