Clinical Trials in Detroit

Showing 8821-8840 of 19,719 trials

Lenalidomide, Dexamethasone, and Elotuzumab With or Without Cyclophosphamide in Treating Patients With Relapsed Primary Amyloidosis

NCT03252600

This randomized phase II trial studies how well lenalidomide, dexamethasone, and eotuzumab with or without cyclophosphamide work in treating patients with primary amyloidosis that has come back after a period of improvement. Drugs used in chemotherapy, such as lenalidomide, dexamethasone, and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as eotuzumab, may interfere with the ability of cancer cells to grow and spread. Giving lenalidomide, dexamethasone, and eotuzumab with cyclophosphamide may work better in treating patients with primary amyloidosis.

Recurrent Primary Amyloidosis

Barbara Ann Karmanos Cancer Institute53 participantsStarted Aug 2017

Duarte, California, United States • Denver, Colorado, United States • Atlanta, Georgia, United States +2 more locations

COMPLETEDPhase 2< 1 mile

Evaluation of Activity and Safety of Oral Selinexor in Participants With Severe COVID-19 Infection

NCT04349098

The main purpose of this study is to evaluate the activity of low dose oral selinexor (KPT-330) and to evaluate the clinical recovery, the viral load, length of hospitalization and the rate of morbidity and mortality in participants with severe COVID-19 compared to placebo. The study had 2 arms and evaluated selinexor 20 mg + standard of care (SoC) and placebo + SoC. As the treatment for COVID-19 is rapidly evolving, the SoC varied over time and across regions of the world.

Coronavirus Infection

Karyopharm Therapeutics Inc190 participantsStarted Apr 2020

Los Angeles, California, United States • Oakland, California, United States • Sacramento, California, United States +30 more locations

Lenalidomide, Dexamethasone, and Elotuzumab With or Without Cyclophosphamide in Treating Patients With Relapsed Primary Amyloidosis

Evaluation of Activity and Safety of Oral Selinexor in Participants With Severe COVID-19 Infection

Find Trials by Condition in Detroit

Radiation Therapy in Treating Patients With Stage II Prostate Cancer

A Phase 1 Study of the CD73 Inhibitor(HLX23) Alone in Participants With Solid Tumor

A Trial to Evaluate Efficacy and Safety of Lenvatinib in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Non Clear Cell Renal Cell Carcinoma (nccRCC) Who Have Not Received Any Chemotherapy for Advanced Disease

Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC

Neihulizumab (ALTB-168) in Patients With Steroid-refractory Acute Graft-versus-host Disease or Treatment-refractory Acute Graft-versus-host Disease

Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients

Patient Empowered Strategy to Reduce Asthma Morbidity in Highly Impacted Populations; PeRson EmPowered Asthma RElief

A Study to Assess How Well Certolizumab Pegol Works in Patients With Moderate to Severe Plaque Psoriasis as Part of Routine Clinical Practice

Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I Disorder

Safety and Efficacy Study of AMG 820 and Pembrolizumab Combination in Select Advanced Solid Tumor Cancer

Metformin in Children With Relapsed or Refractory Solid Tumors

Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx

Investigating Safety, Tolerability and Efficacy of AZD5363 When Combined With Paclitaxel in Breast Cancer Patients

Evaluation Of Clostridium Difficile Vaccine Lot Consistency In Healthy Adults 65 To 85 Years Of Age

Characterization of the Neo-squamous Epithelial Barrier

Cholangioscopy in Primary Sclerosing Cholangitis (PSC)

Online Multi-component Psychological Intervention for Depression, Anxiety and Well-being in 7 Countries

Coronavirus Disease (COvid-)19 REgistry on THROMBOSIS Complications