Clinical Trials in Colorado

Showing 10261-10280 of 13,761 trials

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer

NCT01951690

This is a Phase II, open-label, multicenter, multi cohort, study of VS-6063 (defactinib), a focal adhesion kinase inhibitor, in patients with KRAS mutant non-small cell lung cancer (NSCLC). NSCLC with a KRAS mutation is required for study entry and subjects will be enrolled into 1 of 4 cohorts based on the status of their INK4a/Arf and p53 mutations. The purpose of this study is to demonstrate if VS-6063 (defactinib) improves PFS within each cohort. The safety and tolerability of VS-6063, tumor response rate, progression free survival and overall survival will also be assessed. The pharmacodynamic effects of VS-6063 (defactinib) will be examined in a tumor biopsy and a blood sample.

Non Small Cell Lung CancerLung Cancer

Verastem, Inc.55 participantsStarted Sep 2013

Denver, Colorado, United States • Atlanta, Georgia, United States • Baltimore, Maryland, United States +6 more locations

COMPLETEDPhase 250 miles

Safety, Tolerability and Efficacy of Etelcalcetide in Hemodialysis Patients With Secondary Hyperparathyroidism

NCT01254565

The purpose of this study is to characterize the safety and tolerability and efficacy of multiple ascending doses of etelcalcetide in hemodialysis patients for the treatment of secondary hyperparathyroidism (HPT).

Secondary Hyperparathyroidism

KAI Pharmaceuticals87 participantsStarted Feb 2011

Azusa, California, United States • Costa Mesa, California, United States • Lynwood, California, United States +10 more locations

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer

Safety, Tolerability and Efficacy of Etelcalcetide in Hemodialysis Patients With Secondary Hyperparathyroidism

Find Trials by Condition in Colorado

S0927:Omega3-Fatty Acid Supp in Treating Muscle&Bone Pain&Stiffness in Pts W/Stg I,II,III Brst Canc Rec'v Hormone Thpy

The Effects of Energy Imbalance on Food Intake Behaviors

Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS

Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM)

Progel Vascular Sealant

An Expanded Access, Open-Label Study of Obinutuzumab (GA101) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia

EXTEND (Eltrombopag Extended Dosing Study)

BD FlowSmart™ Subcutaneous Insulin Infusion Set User Preference and Claims Study

Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease

A Study to Assess the Effect and Safety of AZD6765 in Patients With Major Depressive Disorder

Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without Aura

3-year Follow-up Study in Patients Previously Treated With TMC435-Containing Regimen for the Treatment of Hepatitis C Virus Infection

Bipolar Disorder Study for Men and Women

Dose Range Study of Anamorelin in Patients With Non-small Cell Lung Cancer

Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer

Salivary Diagnostic Testing for IVF

Depression in Alzheimer's Disease-2