Clinical Trials in Chicago

Showing 4341-4360 of 20,493 trials

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

NCT04561206

This phase II trial investigates how well brentuximab vedotin and nivolumab work in treating patients with classical Hodgkin lymphoma that has come back after initial treatment (relapsed) or has not responded to initial treatment (refractory). Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to CD30 positive cancer cells in a targeted way and delivers vedotin to kill them. Nivolumab is an antibody that enhances the immune system to better fight Hodgkin lymphoma cells. Giving brentuximab vedotin and nivolumab may be able to defer stem cell transplant treatment and spare the considerable cost and toxicity on transplantation.

Relapsed Classic Hodgkin Lymphoma

City of Hope Medical Center31 participantsStarted Nov 2021

Duarte, California, United States • Chicago, Illinois, United States • Boston, Massachusetts, United States +2 more locations

Enrolling By Invitation2.2 miles

The Course of Hip Flexion Weakness Following LLIF or ALIF

NCT04204135

The purpose of this study is to assess the course of hip weakness after LLIF or ALIF procedures. These outcomes include measures of hip strength using a dynamometer, which is a device used to measure muscle strength. While it is known that people experience temporary hip and leg weakness after an LLIF or ALIF, the exact timing of when hip and leg strength is regained after an LLIF or ALIF is not known.

Degenerative Disc DiseaseHerniated Nucleus PulposusSpondylolisthesis

Rush University Medical Center22 participantsStarted Oct 2018

Chicago, Illinois, United States

COMPLETEDPhase 22.2 miles

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

NCT02070744

The objective of this study was to evaluate the safety and efficacy of VX-661in combination with ivacaftor in participants with cystic fibrosis (CF) who are homozygous for F508del cystic fibrosis transmembrane conductance regulator (CFTR) mutation

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated40 participantsStarted Mar 2014

Birmingham, Alabama, United States • Palo Alto, California, United States • Stanford, California, United States +20 more locations

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

The Course of Hip Flexion Weakness Following LLIF or ALIF

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Find Trials by Condition in Chicago

Single-Sided Deafness and Asymmetric Hearing Loss

Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

Study on Two Adjuvanted Dose Levels of Panblok H7+MF59 Compared for Immunogenicity and Safety With an Unadjuvanted Dose of Panblok H7 in Participants 18 Years of Age and Older

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD)

A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2

A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery

Comparing Hypothermic Temperatures During Hemiarch Surgery

ENCALM: A Study of ENX-102 as a Monotherapy Treatment in Patients With Generalized Anxiety Disorder

Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence

Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors