Clinical Trials in Chicago

Showing 4101-4120 of 9,860 trials

Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD) Extension Study for Subjects Previously Enrolled in Triheptanoin Studies

NCT02214160

The primary objective of this study is to evaluate the long-term safety and efficacy of UX007 in participants with LC-FAOD. The secondary objectives of this study are to evaluate the effect of UX007 on energy metabolism in LC-FAOD and evaluate the impact of UX007 on clinical events associated with LC-FAOD.

Carnitine Palmitoyltransferase (CPT I or CPT II) DeficiencyVery Long Chain Acyl-CoA Dehydrogenase (VLCAD) DeficiencyLong-chain 3-hydroxy-acyl-CoA Dehydrogenase (LCHAD) Deficiency+2 more

Ultragenyx Pharmaceutical Inc94 participantsStarted Dec 2014

San Francisco, California, United States • Washington D.C., District of Columbia, United States • Tampa, Florida, United States +8 more locations

COMPLETEDPhase 32.2 miles

A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC)

NCT02763579

This randomized, Phase I/III, multicenter, double-blinded, placebo-controlled study was designed to evaluate the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 \[PD-L1\] antibody) in combination with carboplatin plus (+) etoposide compared with treatment with placebo + carboplatin + etoposide in chemotherapy-naive participants with ES-SCLC. Participants will be randomized in a 1:1 ratio to receive either atezolizumab + carboplatin + etoposide or placebo + carboplatin + etoposide on 21-day cycles for four cycles in the induction phase followed by maintenance with atezolizumab or placebo until progressive disease (PD) as assessed by the investigator using Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1). Treatment can be continued until persistent radiographic PD or symptomatic deterioration.

Small Cell Lung Carcinoma

Hoffmann-La Roche503 participantsStarted Jun 2016

Fort Myers, Florida, United States • Orlando, Florida, United States • St. Petersburg, Florida, United States +111 more locations

Long-Chain Fatty Acid Oxidation Disorders (LC-FAOD) Extension Study for Subjects Previously Enrolled in Triheptanoin Studies

A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC)

Find Trials by Condition in Chicago

A Physical Activity Program to Disrupt Sedentary Time in Older Latinos

Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During Cervical Dilator Placement Prior to Dilation and Evacuation

A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)

A Technology Assisted Care Transition Intervention for Veterans With CHF or COPD

A Phase III Safety Study of Ferumoxytol Compared to Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia (IDA)

EC-18 for Oral Mucositis in Patients With Concomitant Chemoirradiation

A Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus (SLE)

Vicinium Treatment for Subjects With Non-muscle Invasive Bladder Cancer Previously Treated With BCG

Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors

Cannabidiol Oral Solution for the Treatment of Patients With Prader-Willi Syndrome

Safety, Tolerability, and Immunogenicity of V114 in Healthy Infants (V114-029)

Fingolimod in Preventing Paclitaxel-Associated Neuropathy in Patients With Breast Cancer

Evaluation of C-Scan Capsule in Identifying Subjects With Elevated Risk of Colon Polyps

A Study to Assess the Efficacy, Safety and Tolerability of Rozanolixizumab in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Mifepristone and Two Doses of Misoprostol for Abortion at 11&12 Weeks

A Study to Test the Efficacy and Safety of Bimekizumab and Certolizumab Pegol in Patients With Active Ankylosing Spondylitis

Palliative Care Interventions for Outpatients Newly Diagnosed With Lung Cancer: Phase II

A Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a RO7496998 (AT-527) Study