Clinical Trials in Chicago

Showing 2801-2820 of 9,860 trials

A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT

NCT04766892

This is a Phase 2a proof-of-concept study to assess safety, tolerability, and preliminary efficacy of mavacamten treatment on biomarker levels in participants with heart failure with preserved ejection fraction (HFpEF) and elevation of NT-proBNP with or without elevation of cTnT. Data from this study will inform future study designs of mavacamten in patients with HFpEF.

Heart Failure With Preserved Ejection Fraction

Bristol-Myers Squibb30 participantsStarted Mar 2021

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Tucson, Arizona, United States +18 more locations

TERMINATEDPhase 1/22.2 miles

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT411

NCT04101357

This first-in-human (FIH) trial aimed to establish a safe dose of BNT411 as a monotherapy and in combination with atezolizumab, carboplatin and etoposide. BNT411 is a toll-like receptor 7 (TLR7) agonist which is expected to mount broad innate and adaptive immune reactions, especially in combination with cytotoxic therapies and immune checkpoint inhibitors.

Solid TumorExtensive-stage Small Cell Lung Cancer

BioNTech SE54 participantsStarted Jun 2020

Los Angeles, California, United States • Chicago, Illinois, United States • Greenville, South Carolina, United States +9 more locations

A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT411

Find Trials by Condition in Chicago

PF-06863135 As Single Agent And In Combination With Immunomodulatory Agents In Relapse/Refractory Multiple Myeloma

BIOTRONIK Conduction System Pacing With the Solia Lead

p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study

A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)

Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors

A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases

Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy

Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adult Participants 18 Years of Age and Older

A Study of Etigilimab and Nivolumab in Participants With Locally Advanced or Metastatic Tumors

A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors

Patient Reported Outcomes With WaveLight LASIK

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

A Study of LY3561774 in Participants With Mixed Dyslipidemia

A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure

Method Comparison Study for Measuring Potassium (K) and Ionized Calcium (iCa) in Blood

Precision Study Measuring Potassium (K) in Capillary Specimens