Clinical Trials in California

Showing 3301-3320 of 11,359 trials

First in Human Study With NG-641, a Tumour Selective Transgene Expressing Adenoviral Vector

NCT04053283

To characterise the safety and tolerability of NG-641 in patients with metastatic or advanced epithelial tumours.

Akamis Bio186 participantsStarted Jan 2020

Los Angeles, California, United States • Santa Barbara, California, United States • Celebration, Florida, United States +3 more locations

Active Not RecruitingPhase 3137 miles

Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)

NCT04199689

The purpose of this study is to evaluate the efficacy, immunogenicity and safety of the 9vHPV vaccine in men 20 to 45 years of age. The primary hypothesis tested after the primary database lock is that administration of a 3-dose regimen of 9vHPV vaccine will reduce the incidence of human papillomavirus (HPV) 16/18/31/33/45/52/58-related oral persistent infection (6 months or longer) compared with placebo. There will also be an Extension Study to offer an opportunity to complete the 3 dose regimen of 9vHPV vaccine for participants who received placebo in the Base Study, or received less than 3 doses of 9vHPV vaccine in the Base Study.

Papillomavirus Infections

Merck Sharp & Dohme LLC6,033 participantsStarted Feb 2020

Northridge, California, United States • Rialto, California, United States • Simi Valley, California, United States +100 more locations

First in Human Study With NG-641, a Tumour Selective Transgene Expressing Adenoviral Vector

Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)

Find Trials by Condition in California

Safety and Efficacy of BHV-3000 (Rimegepant) Orally Disintegrating Tablet for the Acute Treatment of Chronic Rhinosinusitis

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients

A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis

PArtial REbreathing for Migraine With Aura 1

A Study to Evaluate the Efficacy and Safety of OTX-TIC (Travoprost) Intracameral Implant for Patients With Open-angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Study of Magrolimab Combinations in Participants With Myeloid Malignancies

NOVOCART®3D for Treatment of Articular Cartilage of the Knee

A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT

7-Day Trial of Sucraid for Alleviating CSID Symptoms in Subjects With Low, Moderate, and Normal Sucrase Levels

BURAN: Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging

A Prospective Observational Study of TPIAT

A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III NSCLC (KEYNOTE-799, MK-3475-799)

Optimal Post Tpa-Iv Monitoring in Ischemic Stroke

Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA

4D-125 in Patients With X-Linked Retinitis Pigmentosa (XLRP)

Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease