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Clinical Trials in California | 5,448 Studies Near You | Clareo Health

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Clinical Trials in California

Discover 5,448 clinical trials near California. Find research studies in your area.

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Breast Cancer Lung Cancer Prostate Cancer Colorectal Cancer Melanoma Leukemia Lymphoma Pancreatic Cancer

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Showing 2601-2620 of 5,448 trials

COMPLETED63 miles

Mobile Cardiac Telemetry and Advanced Multi-Parameter Monitoring in Patients

NCT04754204

To determine the associations among biometric data, arrhythmias, subject-reported symptoms and subject wellness.

Cardiac Arrhythmia

Zoll Medical Corporation585 participantsStarted Dec 2020

Bakersfield, California, United States • Long Beach, California, United States • Los Angeles, California, United States +17 more locations

UNKNOWN117 miles

Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus

NCT04905628

Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus

Diabetes Mellitus

DexCom, Inc.100 participantsStarted Jul 2021

Santa Barbara, California, United States • Aurora, Colorado, United States • Boston, Massachusetts, United States +2 more locations

Find Trials by Condition in California

Breast Cancerin California Lung Cancerin California Prostate Cancerin California Colorectal Cancerin California Melanomain California Leukemiain California Lymphomain California Pancreatic Cancerin California Ovarian Cancerin California Brain Cancerin California

Data from ClinicalTrials.govTerms

UNKNOWNPhase 2/3156 miles

NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection

NCT04452565

This Phase 2/3 trial evaluates four treatment strategies for non-critically ill hospitalized participants (not requiring ICU admission and/or mechanical ventilation) with SARS CoV-2 infection, in which participants will receive NA-831 or Atazanavir with or without Dexamethasone.

Coronavirus InfectionSevere Acute Respiratory InfectionSevere Acute Respiratory Syndrome Coronavirus 2

Biomed Industries, Inc.525 participantsStarted Jun 2022

Los Angeles, California, United States • Orange, California, United States • Palo Alto, California, United States +28 more locations

COMPLETEDPhase 2159 miles

Study Assessing AR-1105 in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO)

NCT03739593

This study will evaluate the safety, tolerability and efficacy of AR-1105 (dexamethasone implant) for the treatment of macular edema (ME) due to retinal vein occlusion (RVO). A more durable intravitreal implant containing a low dose of dexamethasone may result in less frequent retreatments, and potentially lower the incidence of steroid-related side effects without compromising efficacy.

Aerie Pharmaceuticals49 participantsStarted Mar 2019

Phoenix, Arizona, United States • Beverly Hills, California, United States • Palo Alto, California, United States +8 more locations

COMPLETEDPhase 2/3159 miles

PF-06651600 for the Treatment of Alopecia Areata

NCT03732807

This is a global Phase 2b/3 study to evaluate the safety and effectiveness of an investigational study drug (called PF-06651600) in adults and adolescents (12 years and older) who have 50% or greater scalp hair loss. The study is placebo-controlled, meaning that some patients entering the study will not receive active study drug but will receive tablets with no active ingredients (a placebo). This is a dose-ranging study, investigating 5 different dosing regimens. It will be double-blinded, meaning that the sponsor, the study doctors, the staff, and the patients will not know whether a patient is on active study drug (or the dose) or placebo.

Alopecia Areata

Pfizer718 participantsStarted Dec 2018

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Birmingham, Alabama, United States +152 more locations

COMPLETEDPhase 3164 miles

Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients

NCT02851407

This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric patients undergoing hematopoietic stem cell transplant who are at high risk or very high risk of developing VOD.

Veno-occlusive Disease

Jazz Pharmaceuticals372 participantsStarted Sep 2016

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Tucson, Arizona, United States +111 more locations

COMPLETEDPhase 1/2164 miles

Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

NCT02178722

The purpose of this study was to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in participants with certain cancers. This study was conducted in 2 phases, Phase 1 and Phase 2.

Microsatellite-instability (MSI) High Colorectal Cancer (CRC)Endometrial CancerHead and Neck Cancer+11 more

Incyte Corporation444 participantsStarted Jul 2014

La Jolla, California, United States • Los Angeles, California, United States • Sacramento, California, United States +21 more locations

COMPLETEDPhase 3167 miles

Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD)

NCT00366145

The purpose of this study is to evaluate the efficacy and gather additional safety information for Prochymal® in participants who have failed to respond to steroid treatment of Grades B-D acute GVHD.

Graft Versus Host Disease

Mesoblast, Inc.260 participantsStarted Aug 2006

Birmingham, Alabama, United States • Tucson, Arizona, United States • Duarte, California, United States +67 more locations

TERMINATEDPhase 2173 miles

Safety and Efficacy of AMG 827 in Subjects With RA

NCT01059448

This is an extension study for subjects who participated in Protocol 20090061 (NCT00950989). All subjects in this study will receive a 210mg injection of AMG827 for treatment for their Rheumatoid Arthritis for up to 5 years.

Rheumatoid Arthritis

Amgen211 participantsStarted Jun 2010

Scottsdale, Arizona, United States • Tucson, Arizona, United States • La Jolla, California, United States +41 more locations

COMPLETEDPhase 3175 miles

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

NCT02636946

This study will evaluate the intraocular pressure (IOP)-lowering effect and safety of Bimatoprost SR compared with selective laser trabeculoplasty in participants with open-angle glaucoma or ocular hypertension who are not adequately managed with topical IOP-lowering medication for reasons other than medication efficacy (e.g., due to intolerance or nonadherence).

GlaucomaOpen-Angle Ocular Hypertension

Allergan144 participantsStarted Feb 2016

Dothan, Alabama, United States • Chandler, Arizona, United States • Chandler, Arizona, United States +30 more locations

COMPLETEDPhase 1/2184 miles

A Study to Assess the Safety, Tolerability, and Efficacy of Long-term SOBI003 Treatment in Pediatric MPS IIIA Patients

NCT03811028

MPS IIIA, also known as Sanfilippo A, is an inherited lysosomal storage disease (LSD). MPS IIIA is caused by a deficiency in sulfamidase, one of the enzymes involved in the lysosomal degradation of the glycosaminoglycan (GAG) heparan sulfate (HS). The natural course of MPS IIIA is characterized by devastating neurodegeneration with initially mild somatic involvement. The aim of the present study is to assess the safety, tolerability and efficacy of long-term SOBI003 treatment. SOBI003 is a chemically modified recombinant human (rh) Sulfamidase developed as an enzyme replacement therapy (ERT).

Sanfilippo Syndrome Type A (MPS IIIA)

Swedish Orphan Biovitrum6 participantsStarted Jan 2019

Oakland, California, United States • Chapel Hill, North Carolina, United States • Ankara, Turkey (Türkiye)

COMPLETEDPhase 3187 miles

Herniorrhaphy Study for Opioid Elimination

NCT03907176

This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal analgesic (MMA) regimen. The study will be conducted in 2 sequential parts: Part 1 is randomized and Part 2 is Investigator's preference for MMA regimen.

Heron Therapeutics115 participantsStarted Apr 2019

Anaheim, California, United States • La Mesa, California, United States • La Mesa, California, United States +27 more locations

COMPLETED190 miles

Nonalcoholic Fatty Liver Disease (NAFLD) Adult Database 2

NCT01030484

The NAFLD Database 2 will recruit at least 1,500 new adult participants suspected or known to have NAFLD or nonalcoholic steatohepatitis (NASH)-related cirrhosis and will also invite adult participants from the prior NAFLD Database and related studies (PIVENS trial and TONIC trial) to enroll in the NAFLD Database 2. To elucidate, through the cooperative effort of a multidisciplinary and multicenter group of collaborators, the etiology, natural history, diagnosis, treatment, and prevention of NAFLD, and in particular its more severe form of NASH and its complications.

Johns Hopkins Bloomberg School of Public Health2,501 participantsStarted Dec 2009

La Jolla, California, United States • San Francisco, California, United States • Indianapolis, Indiana, United States +5 more locations

TERMINATEDPhase 1197 miles

A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in Combination With Hu5F9-G4 to Patients With Relapsed and/or Refractory Acute Myeloid Leukemia

NCT03922477

This Phase Ib study is designed to evaluate the safety and pharmacokinetics of atezolizumab when given in combination with Hu5F9-G4 to patients with relapsed or refractory (R/R) acute myeloid leukemia (AML).

Acute Myeloid Leukemia

Hoffmann-La Roche13 participantsStarted Oct 2019

Sacramento, California, United States • New Haven, Connecticut, United States • New York, New York, United States +1 more locations

COMPLETEDPhase 2197 miles

Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia

NCT00352365

This phase II trial is studying how well lenalidomide works in treating older patients with acute myeloid leukemia with abnormal chromosome 5q. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing.

Adult Acute Basophilic LeukemiaAdult Acute Eosinophilic LeukemiaAdult Acute Megakaryoblastic Leukemia (M7)+14 more

National Cancer Institute (NCI)41 participantsStarted Jun 2006

Little Rock, Arkansas, United States • Redding, California, United States • Roseville, California, United States +51 more locations

COMPLETEDPhase 4530 miles

A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis

NCT02790138

The purpose of this study is to compare the efficacy of vedolizumab intravenous (IV) and placebo in terms of the percentage of participants with chronic or recurrent pouchitis achieving clinically relevant remission.

Takeda102 participantsStarted Oct 2016

Chicago, Illinois, United States • Evanston, Illinois, United States • Minneapolis, Minnesota, United States +31 more locations

COMPLETEDPhase 2668 miles

Copanlisib in Treating Patients With Persistent or Recurrent Endometrial Cancer

NCT02728258

This phase II trial studies how well copanlisib works in treating patients with endometrial cancer that has not decreased or disappeared, and the cancer may still be in the body despite treatment (persistent) or has come back (recurrent). Copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Endometrial Endometrioid AdenocarcinomaEndometrial Mixed Cell AdenocarcinomaEndometrial Serous Adenocarcinoma+3 more

NRG Oncology11 participantsStarted Sep 2016

New Haven, Connecticut, United States • Deerfield Beach, Florida, United States • Miami, Florida, United States +40 more locations

COMPLETEDPhase 1668 miles

Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma

NCT02248805

The primary goal of this Phase 1 study is to characterize the safety and tolerability of MGD007 and establish the maximum tolerated dose (MTD) and schedule of MGD007 administered to patients with metastatic colorectal carcinoma. Pharmacokinetics, pharmacodynamics, and the anti-tumor activity of MGD007 will also be assessed.

Colorectal Carcinoma

MacroGenics95 participantsStarted Oct 2014

New Haven, Connecticut, United States • Tampa, Florida, United States • Baltimore, Maryland, United States +5 more locations

COMPLETEDPhase 1805 miles

Study of ACY-1215 in Combination With Lenalidomide, and Dexamethasone in Multiple Myeloma

NCT01583283

The purpose of this study is to determine the best dose of ACY-1215 in combination with lenalidomide and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma. Once determined, the purpose of this study will be to determine the efficacy of ACY-1215 in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma who have had 1-3 prior therapies and who are not lenalidomide-refractory.

Multiple Myeloma

Celgene38 participantsStarted Jul 2012

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Chapel Hill, North Carolina, United States +2 more locations

COMPLETEDPhase 2838 miles

Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)

NCT03688074

A phase 2, multicentre, randomized, double-blind, placebo-controlled, parallel group study to evaluate the effect of tezepelumab on airway inflammation in adults with inadequately controlled asthma.

AsthmaBronchial DiseasesRespiratory Tract Diseases+6 more

AstraZeneca116 participantsStarted Nov 2018

Denver, Colorado, United States • New Haven, Connecticut, United States • Boston, Massachusetts, United States +25 more locations

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