Clinical Trials in Baltimore

Showing 14981-15000 of 23,464 trials

Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

NCT01664741

The proposed research will provide significant new gender-specific information of scientific and clinical relevance on the function of the mu-opioid system in nicotine dependence and therapeutic effectiveness of nicotine replacement therapy (NRT). The studies will help to explain the differences in the prevalence of smoking in men and women, sex-specific differences in nicotine craving and withdrawal as well as the poorer therapeutic response to NRT. This work may pave the way to the design of improved pharmacotherapies that can more effectively target the endogenous opioid system in the treatment of nicotine dependence.

Nicotine Dependence

Johns Hopkins University127 participantsStarted Apr 2012

Baltimore, Maryland, United States

COMPLETEDPhase 1< 1 mile

Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers

NCT01162486

The aim of this study is to evaluate (1) the safety and tolerability of escalating doses of rifapentine (RPT) administered daily by oral; (2) the effect of increasing doses of RPT on cytochrome P450 isoform 3A (CYP3A) enzyme metabolizing activity, using single-dose midazolam (MDZ); and (3) the effect of increasing doses of RPT on autoinduction of RPT metabolism.

TuberculosisTuberculosis, Pulmonary

Johns Hopkins University37 participantsStarted Apr 2010

Baltimore, Maryland, United States

Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers

Find Trials by Condition in Baltimore

A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors

A Phase 2a, Proof-of-Concept Study of GIC-1001 in the Management of Visceral Pain During Sedation-Free, Full Colonoscopy

Berry Components and Blood Sugar & Fat Metabolism

Long-term Safety and Efficacy of Sirukumab in Participants With RA Completing Studies CNTO136ARA3002 or CNTO136ARA3003

A Controlled Trial of Serotonin Reuptake Inhibitors Added to Stimulant Medication in Youth With Severe Mood Dysregulation

LIVE-C-Free: Early and Late Treatment of Hepatitis C With Sofosbuvir/Ledipasvir in Liver Transplant Recipients

Academic Achievement in Children With Asthma

A 6-month Clinical Study to Evaluate the Effect of a Digital Disease Management Tool in Patients With T2DM

Operative Versus Nonoperative Treatment of Humeral Shaft Fractures: A Prospective Cohort Comparison Study

Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment

A Phase2 of A-101 Topical Solution in Subjects With Common Warts

A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants

Melody® Transcatheter Pulmonary Valve Post-Approval Study

Safety and Tolerability of Tozadenant as Adjunctive Therapy in Levodopa-Treated Patients With Parkinson's Disease.

Study To Evaluate Pf-04965842 In Subjects With Moderate To Severe Atopic Dermatitis

A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalized Seizures.

Safety Study of Enzalutamide (MDV3100) in Patients With Incurable Breast Cancer

Risperidone Long-acting Versus Oral Risperidone in Patients With Schizophrenia and Alcohol Use Disorder