Clinical Trials in Baltimore

Showing 10181-10200 of 17,842 trials

Harnessing Placebo Effects in Methadone Treatment

NCT02941809

More than 2 million individuals in the United States have an Opioid Use Disorder (OUD). Methadone maintenance treatment is the gold standard of medication-assisted treatment for OUD, but high-dose methadone is associated with cardiotoxicity and respiratory complications, among other side effects. These adverse effects make enhancing the effectiveness of lower doses of methadone an attractive therapeutic goal. Long recognized for its capacity to enhance treatment outcomes for a wide range of neuropsychiatric disorders including pain, the placebo effect offers an as-yet untested avenue to such an enhancement. This approach is particularly compelling given that individuals with substance use disorder tend to have higher salience attribution, and may thereby be more sensitive to placebo effects. Our study combines two promising clinical methodologies-open-label placebo and conditioning-to investigate whether placebo effects can increase the effective potency of methadone in treatment-seeking OUD patients.

Opioid-use DisorderOpioid-Related Disorders

University of Maryland, Baltimore133 participantsStarted Dec 2017

Baltimore, Maryland, United States

COMPLETEDPhase 2< 1 mile

Safety and Efficacy of a Lysophosphatidic Acid Receptor Antagonist in Idiopathic Pulmonary Fibrosis

NCT01766817

The purpose of this study is to determine if study drug (BMS-986020) dose of 600 mg once daily or 600 mg twice daily for 26 weeks compared with placebo will reduce the decline in forced vital capacity (FVC) and will be well tolerated in subjects with idiopathic pulmonary fibrosis (IPF).

Idiopathic Pulmonary Fibrosis

Bristol-Myers Squibb325 participantsStarted Jan 2013

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Los Angeles, California, United States +69 more locations

Harnessing Placebo Effects in Methadone Treatment

Safety and Efficacy of a Lysophosphatidic Acid Receptor Antagonist in Idiopathic Pulmonary Fibrosis

Find Trials by Condition in Baltimore

A Study to Assess the Efficacy and Safety of Abatacept in Adults With Active Primary Sjögrens Syndrome

Bortezomib, Ifosfamide, Carboplatin, and Etoposide, With or Without Rituximab, in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin Lymphoma

Virtual Reality During Procedures in Pediatric Patients

Co-Administration of AS03 Adjuvanted A/H7N9 IIV With IIV4

Blood Sample Collection to Evaluate Biomarkers for Hepatocellular Carcinoma

Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS)

Solid Tumors Using Ixabepilone and Dasatinib

Comminuted Intra-Articular Distal Tibia Fracture Fixation Using Computer Techniques

Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS)

Study of MLN2480 in Participants With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Participants With Metastatic Melanoma

A Rollover Safety Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Alpha Lipoic Acid in Geographic Atrophy

Efficacy and Safety of Intravenous Neridronic Acid in CRPS

TMT Fusion Plate vs. Two Crossed Screws

Clinical Evaluation of Etafilcon A Contact Lenses Using a Novel Manufacturing Technology

Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid Tumors

Study of the Safety, Pharmacodynamics, Efficacy, and PK of TIMP-GLIA in Subjects With Celiac Disease

Study of the Native Outflow Tract Transcatheter Pulmonary Valve (TPV)