Clinical Trials in Baltimore

Showing 9661-9680 of 17,842 trials

A Study of ONCO-DOX in Locally Advanced Hepatocellular Carcinoma

NCT02460991

This is a prospective, multicenter study that will be conducted at up to 40 centers in the United States and Outside United States (OUS). Participants in the study will be randomly assigned to receive either ONCO-DOX or sorafenib treatment. This study will evaluate the study participants' outcomes (medical condition) after being treated with ONCO-DOX and compare it to those treated with sorafenib alone.

Hepatocellular CarcinomaHepatomaLiver Cell Carcinoma

Boston Scientific Corporation2 participantsStarted Nov 2015

Birmingham, Alabama, United States • Los Angeles, California, United States • Louisville, Kentucky, United States +3 more locations

COMPLETEDNA< 1 mile

Randomized Trial to Assess PO Versus IV Antibiotics

NCT01714596

The goal of this study is to evaluate the effect of treatment of post-op wound infection in long bones after fracture fixation or joint fusion and either: (Group 1) operative debridement and PO antibiotic treatment for 6 weeks; or (Group 2) operative debridement and IV antibiotics for 6 weeks. Primary Hypothesis 1: The rate of study injury related surgical interventions by one year in Group 1 will be non-inferior to the rate in Group 2. Secondary Hypothesis 1: The rate of treatment failure by one year in Group 1 will be non-inferior to the rate in Group 2. Treatment failure is defined as wound problems that require surgery \>2 weeks after initial debridement, infection recurrence, infection with a new pathogen, joint erosion, implant failure, medical problems related to the treatment administration which necessitates a switch from one arm to the other. Secondary Hypothesis 2: The rate of re-hospitalization for complications, infection, non-union and amputation by one year in Group 1 will be non-inferior to the rate in Group 2. Secondary Hypothesis 3: Following discharge for treatment of infection, per patient treatment costs at 1 year will be lower in Group 1 than in Group 2. Secondary Hypothesis 4: Adherence in Group 1 will be non-inferior to adherence in Group 2. Secondary Hypothesis 5: Patient satisfaction with treatment in Group 1 will be non-inferior to adherence in Group 2. Specific Aim 2: To build and validate a risk prediction model for failure of treatment of early post-op wound infections after fixation of fractures and joint fusions.

Wound Infection

Major Extremity Trauma Research Consortium233 participantsStarted Dec 2013

Birmingham, Alabama, United States • Los Angeles, California, United States • San Francisco, California, United States +21 more locations

A Study of ONCO-DOX in Locally Advanced Hepatocellular Carcinoma

Randomized Trial to Assess PO Versus IV Antibiotics

Find Trials by Condition in Baltimore

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Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease

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