Clinical Trials in Baltimore

Showing 5821-5840 of 17,842 trials

Safety and Suitability of Supplementing Early MIP Surgery (MIPS) of ICH With Pioglitazone

NCT05582707

This is an exploratory single-center prospective study of 20 subjects with primary basal ganglia ICH who will receive early MIPS in combination with perioperative pioglitazone treatment. Outcomes will be compared to matched subjects with basal ganglia ICH who undergo MIPS alone as part of the ENRICH trial. This study will take approximately two years to complete.

Intracerebral Haemorrhage, Intraventricular

University of Maryland, Baltimore1 participantsStarted May 2023

Baltimore, Maryland, United States

COMPLETEDPhase 2< 1 mile

Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease

NCT04376684

OSCAR (Otilimab in Severe COVID-19 Related Disease) is a multi-center, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of otilimab for the treatment of severe pulmonary COVID-19 related disease. The study is being conducted in 2 parts (Part 1 and Part 2). Otilimab is a human monoclonal anti-granulocyte macrophage colony stimulating factor (GM-CSF) antibody that has not previously been tested in participants with severe pulmonary COVID-19 related disease in Part 1. The aim of this study is to evaluate the benefit-risk of a single infusion of otilimab in the treatment of hospitalized participants with severe COVID-19 related pulmonary disease with new onset hypoxia requiring significant oxygen support or requiring early invasive mechanical ventilation (less than or equal to \[\<=\] 48 hours before dosing). Participants will be randomized to receive a single intravenous (IV) infusion of otilimab or placebo, in addition to standard of care.

Severe Acute Respiratory Syndrome

GlaxoSmithKline1,156 participantsStarted May 2020

Mobile, Alabama, United States • Little Rock, Arkansas, United States • Sacramento, California, United States +117 more locations

Safety and Suitability of Supplementing Early MIP Surgery (MIPS) of ICH With Pioglitazone

Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease

Find Trials by Condition in Baltimore

A Study to Characterize the Outcomes of Olaparib Maintenance Monotherapy in Newly Diagnosed BRCAwt Ovarian Cancer

Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

A Study of Rilematovir (JNJ-53718678) in Adult Outpatients With Respiratory Syncytial Virus (RSV) Infection

To Assess the Safety and Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma

A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 in Pediatric Subjects With MMA

Long-term Clinical Correlates of Traumatic Brain Injury

Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK

Extension Study of Patidegib Topical Gel, 2% in Subjects With Gorlin Syndrome (Basal Cell Nevus Syndrome)

A Study of Semorinemab in Patients With Moderate Alzheimer's Disease

A Study to Evaluate the Long-term Safety and Efficacy of Deucravacitinib in Participants With Crohn's Disease or Ulcerative Colitis

Prostate Imaging Using MRI +/- Contrast Enhancement

Air Optix® Night and Day® Aqua Continuous Wear

Randomized Controlled Trial for Vestibular Treatment in Concussion

Study of a Combination of GSK1795091 and Immunotherapies in Subjects With Advanced Solid Tumors

Study of AZD9291 Plus MEDI4736 Versus AZD9291 Monotherapy in NSCLC After Previous EGFR TKI Therapy in T790M Mutation Positive Tumours

An Open-Label Study of Trofinetide for the Treatment of Girls Two to Five Years of Age Who Have Rett Syndrome

Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations