Clinical Trials in Baltimore

Showing 541-560 of 23,476 trials

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

NCT07580339

The purpose of this study is to evaluate the safety and clinical activity of combining DCSZ11 with radiation and capecitabine/oxaliplatin (CAPOX) for the neoadjuvant treatment of patients with mismatch repair proficient (pMMR) high risk locally advanced rectal cancer.

Rectal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins30 participantsStarted Jul 2026

Baltimore, Maryland, United States

RECRUITINGPhase 3< 1 mile

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

NCT07218029

Researchers are looking for more ways to treat PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow. This causes high blood pressure in the lungs and overworks the heart. PAH can make it hard to breathe and be active. Some standard (usual) treatments for PAH can treat symptoms of PAH but do not stop PAH from getting worse. Sotatercept is a study medicine designed to treat PAH. It is a targeted therapy, which is a treatment that works on certain proteins that play a role in causing PAH. This is a long-term follow-up (LTFU) study. People who took part in certain other studies testing sotatercept for PAH may be able to join this study. The goal of this study is to learn about the long-term safety of sotatercept and if people tolerate it when taken with standard PAH treatment over a longer period of time.

Pulmonary Arterial Hypertension

Merck Sharp & Dohme LLC815 participantsStarted May 2021

Phoenix, Arizona, United States • La Jolla, California, United States • San Francisco, California, United States +104 more locations

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

Find Trials by Condition in Baltimore

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

The Ailliance Post-Market Clinical Study

Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

Turner Syndrome: Genetic Considerations

Long-Term Follow-up of People Undergoing Hematopoietic Stem Cell Transplantation

Natural History of Noncirrhotic Portal Hypertension

Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing

The Percutaneous Transmural Arterial Bypass -1 Study (Post Approval Registry)

A Study of DR-01 in Subjects With Alopecia Areata and Vitiligo

Management of the PDA Trial

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

An Extension Trial to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)