Clinical Trials in Baltimore

Showing 5101-5120 of 17,842 trials

Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence

NCT02111798

This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder. Participants also earned financial incentives for providing urine samples that tested negative for cocaine. Bupropion was examined for this purpose because of its previously demonstrated efficacy and safety as well as its pharmacological actions at dopamine systems. Participants were randomly assigned to bupropion XL vs. placebo and received different incentive schedules depending on whether they demonstrated abstinence from cocaine early in the study. Outcomes were tracked over a 6-month time frame and the overarching hypothesis was that bupropion (as compared to placebo) would increase the number of urine samples testing negative for cocaine, independent of whether participants demonstrated abstinence from cocaine early in the study.

Substance AbuseCocaine Dependence

Johns Hopkins University83 participantsStarted Jul 2014

Baltimore, Maryland, United States • Baltimore, Maryland, United States

COMPLETEDPhase 2< 1 mile

A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans

NCT02360371

Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.

Opioid SensitivityIndividual DifferenceAbuse Opioids

Johns Hopkins University100 participantsStarted Apr 2015

Baltimore, Maryland, United States

Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence

A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans

Find Trials by Condition in Baltimore

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

A Study to Evaluate AAV9 Neutralizing Antibody Seroconversion in Household Contacts.

Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use

NXT Post-Market Clinical Follow-up

A Study of AK104, a PD-1/CTLA-4 Bispecific Antibody in Subjects With Recurrent/Metastatic Cervical Cancer

Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

Safety and Effectiveness Study of Endovascular Abdominal Aortic Aneurysm Repair Using the Nellix® System

A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome

Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention

Multicenter Hologic Tomosynthesis Study

First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors

A Safety Trial of Lisocabtagene Maraleucel (JCAR017) for Relapsed and Refractory (R/R) B-cell Non-Hodgkin Lymphoma (NHL) in the Outpatient Setting (TRANSCEND-OUTREACH-007)

ThRombosis ExclUsion STudy

Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria

A Phase 2b Study of Icosabutate in Fatty Liver Disease

Oral EPI-7386 in Patients with Castration-Resistant Prostate Cancer

S1014 Abiraterone Acetate in Treating Patients With Prostate Cancer Who Have Undergone Initial Hormone Therapy

Phase 2 Study of Efficacy and Safety of AK120, in Subjects With Moderate-to-Severe Atopic Dermatitis