Clinical Trials in Austin

Showing 741-760 of 15,205 trials

PD, PK, and Safety of ALTO-203 in Patients With MDD

NCT06391593

The goal of this clinical trial is to determine the pharmacodynamic effects of ALTO-203 in patients with MDD in a randomized, placebo-controlled, single-dose crossover treatment period. Additionally, safety, tolerability, and PK will be assessed in a subsequent randomized placebo-controlled multi-dose parallel-group treatment period of 28 days. Participants will complete subjective response questionnaires and perform cognitive tasks during the single-dose period, in which participants will receive ALTO-203 25 μg and 75 μg, as well as placebo. During the multiple-dose period, participants will receive either ALTO-203 25 μg, 75 μg , or placebo. Safety will be assessed over the single dose and 28-day multiple dose periods.

Major Depressive DisorderAnhedonia

Alto Neuroscience69 participantsStarted Mar 2024

Tucson, Arizona, United States • Oceanside, California, United States • Torrance, California, United States +12 more locations

Active Not RecruitingPhase 4< 1 mile

Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial

NCT05610319

This study will assess a pragmatic, treat and extend regimen of faricimab against the standard of a fixed dosing regimen.

Diabetic Macular Edema

McMaster University446 participantsStarted May 2023

Modesto, California, United States • Sacramento, California, United States • Oak Forest, Illinois, United States +43 more locations

PD, PK, and Safety of ALTO-203 in Patients With MDD

Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial

Find Trials by Condition in Austin

A Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Participants With Advanced MASH Liver Fibrosis

Pilot Trial for WounDx™ Clinical Decision Support Tool

Can Escalation Reduce Acute Myocardial Infarction Mortality in Cardiogenic Shock

Molecular Profiling in Tissue Samples From Patients With Cancer Who Are Exceptional Responders to Treatment

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus

Study of GS-9911 With or Without Antibody Treatment for Adults With Solid Tumors

Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

The PREDICT Registry:

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer

Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine

Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

A Study to Investigate the Pharmacokinetics of Tirabrutinib in Participants With Mild, Moderate, and Severe Hepatic Impairment Compared to Healthy Participants

Quality of Life After Treatment for Bladder Cancer: The Bladder Cancer Survivorship Study

MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)