Rheumatoid Arthritis Clinical Trials

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Implementation of Neuro Lung Protective Ventilation

NCT03243539

Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury. It is proven that using lower ventilator volume settings improves outcomes. In patients with acute brain injury, it is proven that maintaining a normal partial pressure of carbon dioxide in the arterial blood improves outcomes. Mechanical ventilator settings with higher volumes and higher breathing rates are sometimes required to maintain a normal partial pressure of carbon dioxide. These 2 goals of mechanical ventilation, using lower volumes to prevent additional lung injury but maintaining a normal partial pressure of carbon dioxide, are both important for patients with acute brain injury. The investigators have designed a computerized ventilator protocol in iCentra that matches the current standard of care for mechanical ventilation of patients with acute brain injury by targeting a normal partial pressure of carbon dioxide with the lowest ventilator volume required. This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a standard of care mechanical ventilation protocol for patients with acute brain injury in the iCentra electronic medical record system at Intermountain Medical Center. We hypothesize that implementation of a standardized neuro lung protective ventilation protocol will be feasible, will achieve a target normal partial pressure of carbon dioxide, will decrease tidal volumes toward the target 6 mL/kg predicted body weight, and will improve outcomes.

Acute Brain InjuryTraumatic Brain InjuryIntracerebral Hemorrhage+3 more

Colin Grissom728 participantsStarted Aug 2017

Murray, Utah, United States

TERMINATEDPhase 1/2

In-vivo Regulatory T Cell Enhancement With Cyclophosphamide and Sirolimus

NCT01453140

In this study the investigators are proposing to treat patients with steroid-refractory Graft-versus-host Disease (GVHD) stabilization using IL-2 and azacitidine

Graft Versus Host Disease

Hackensack Meridian Health3 participantsStarted Aug 2011

Hackensack, New Jersey, United States

Implementation of Neuro Lung Protective Ventilation

In-vivo Regulatory T Cell Enhancement With Cyclophosphamide and Sirolimus

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