Rheumatoid Arthritis Clinical Trials

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An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)

NCT07392255

This is a clinical study to evaluate the safety, tolerability and efficacy of CTx001, administered via a single subretinal injection, for GA (secondary to AMD). Safety and efficacy will be measured at regular intervals for 2 years after which long-term safety will be assessed annually for up to 5 years.

Geographic Atrophy Secondary to Age-related Macular Degeneration

Complement Therapeutics75 participantsStarted Dec 2025

Carmel, Indiana, United States • Reno, Nevada, United States • Dallas, Texas, United States +1 more locations

RECRUITINGPhase 1

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

NCT05869955

The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory autoimmune diseases (Breakfree-1).

Systemic Lupus ErythematosusIdiopathic Inflammatory MyopathySystemic Sclerosis+1 more

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company270 participantsStarted Sep 2023

Aurora, Colorado, United States • Denver, Colorado, United States • New Haven, Connecticut, United States +51 more locations

An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

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