Rheumatoid Arthritis Clinical Trials

Showing 6641-6660 of 35,946 trials

Acetaminophen Before Surgery Lowers Postop Pain in Pediatric Solid Tumor Patients (ERAS)

NCT07095816

Pain is the predominant subjective symptom experienced during the perioperative period in pediatric patients with solid tumors. Intense pain may impede early postoperative activities and delay the recovery process. Preemptive analgesia，as a component of multimodal analgesia strategies，aims to mitigate pain by administering analgesic interventions prior to the application of a noxious stimulus. This approach seeks to diminish both peripheral and central sensitization to pain，thereby alleviating postoperative pain. Currently，while preoperative acetaminophen is widely used in adult surgeries，research is limited for its use in pediatrics. This study aims to evaluate the impact of preemptive acetaminophen on reducing postoperative pain in children with solid tumors under the mode of ERAS.

AnalgesicEnhanced Recovery After SurgeryPostoperative Pain+2 more

Nanjing Children's Hospital182 participantsStarted May 2023

Nanjing, Jiangsu, China

TERMINATEDPhase 1/2

MGC018 With or Without MGA012 in Advanced Solid Tumors

NCT03729596

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of vobramitamab duocarmazine (MGC018) in patients with advanced solid tumors. Patients with solid tumors will be enrolled in the Dose Escalation Phase; Cohort Expansion will include metastatic castrate-resistant prostate cancer (mCRPC), non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), squamous cell carcinoma of the head and neck (SCCHN), and melanoma. Patients who do not experience unacceptable toxicity or meet criteria for permanent discontinuation may undergo additional cycles for up to two years. Patients in Cohort Expansion will be followed for survival every 3 months for 2 years following last dose.

Squamous Cell Carcinoma of Head and NeckTriple Negative Breast CancerMelanoma+3 more

MacroGenics143 participantsStarted Nov 2018

Santa Monica, California, United States • Washington D.C., District of Columbia, United States • Baltimore, Maryland, United States +18 more locations

Acetaminophen Before Surgery Lowers Postop Pain in Pediatric Solid Tumor Patients (ERAS)

MGC018 With or Without MGA012 in Advanced Solid Tumors

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