Rheumatoid Arthritis Clinical Trials

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Safety, Efficacy and Pharmacokinetics of ThisCART19A in Patients With Refractory or Relapsed B Cell Lymphoma

NCT05535673

This is a single dose escalation study to evaluate the safety, efficacy and pharmacokinetics of ThisCART19A (Allogeneic CAR-T targeting CD19) in patients with refractory or relapsed CD19 positive B cell Lymphoma.

Allogeneic, CAR-T, Protein Sequestration, Non-gene Edited, r/r B-NHL

Zhengzhou University15 participantsStarted Sep 2022

COMPLETEDNA

Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia

NCT05535036

The management of postpartum pain is essential to ensure early rehabilitation for parturients. Intravenous dexamethasone has a potent analgesic action when used in the context of general anesthesia. Nevertheless, it remains poorly studied in combination with spinal anesthesia (SA). The aim of this study was to assess the analgesic effect of intravenous dexamethasone after caesarean section under SA. Methods: We conducted a prospective, randomized, double-blinded study including 84 ASA II-III parturient at term who were proposed for caesarean section under SA. Parturient were randomized into two groups: Dexamethasone group (DG) who received 8mg of intravenous dexamethasone (2ml) immediately after SA and placebo group (PG) who received 2ml of isotonic saline. The analgesic protocol was standardized and we opted for Tramadol as rescue analgesic. The main outcome is the use of Tramadol in the first 24 hours postpartum..

Cesarean SectionDexamethasonePostoperative Pain+1 more

Mongi Slim Hospital84 participantsStarted Feb 2020

La Marsa, Tunis Governorate, Tunisia

Safety, Efficacy and Pharmacokinetics of ThisCART19A in Patients With Refractory or Relapsed B Cell Lymphoma

Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia

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