Rheumatoid Arthritis Clinical Trials

Showing 20941-20960 of 47,334 trials

ADVM-022 Intravitreal Gene Therapy for Wet AMD

NCT03748784

ADVM-022 (AAV.7m8-aflibercept) is a gene therapy product developed for the treatment of neovascular (wet) age-related macular degeneration (wet AMD). Wet AMD is a serious condition and the leading cause of blindness in the elderly. The available therapies for treating wet AMD require life-long intravitreal (IVT) injections every 4-12 weeks to maintain efficacy. A one-time IVT administration of ADVM-022 has the potential to treat wet AMD by providing durable expression of therapeutic levels of intraocular anti-VEGF protein (aflibercept) and maintaining the vision of patients. ADVM-022 is designed to reduce the current treatment burden which often results in undertreatment and vision loss in patients with wet AMD receiving anti-VEGF therapy in clinical practice.

Adverum Biotechnologies, Inc.30 participantsStarted Nov 2018

Bakersfield, California, United States • Beverly Hills, California, United States • Golden, Colorado, United States +8 more locations

COMPLETEDNA

Risk Stratification-directed Therapy for AML With t(8;21) /AML1-ETO+

NCT02936089

Acute myeloid leukemia with t(8;21) /AML1-ETO-positive (AE AML) is a heterogeneous disease entailing different prognoses. There were significant differences in the therapeutic effect between different subgroups of AE AML. Therefore, risk stratification-directed therapy is very necessary for AE AML.

Acute Myeloid LeukemiaRisk Stratification

Nanfang Hospital, Southern Medical University207 participantsStarted Oct 2016

ADVM-022 Intravitreal Gene Therapy for Wet AMD

Risk Stratification-directed Therapy for AML With t(8;21) /AML1-ETO+

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