Rheumatoid Arthritis Clinical Trials in New York

Showing 1781-1800 of 4,168 trials

Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

NCT00983814

Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder characterized by lifelong issues of inattention, distraction, organizational difficulties, forgetfulness, restlessness, talking out of turn, difficulty waiting and interrupting others. ADHD is the second most common neuropsychiatric disorder affecting 4.4% of the United States (US) adult population, or between 8-9 million individuals. Droxidopa (L-dihydroxyphenylserine (L-DOPS)) is a synthetic catecholamine which is converted to norepinephrine (NE) via decarboxylation, resulting in increased levels of NE centrally in the central nervous system (CNS) and peripherally. Co-treatment with carboxylase inhibitors, such as carbidopa, given with droxidopa, can increase the CNS levels of NE with greater crossing of the blood-brain barrier. Droxidopa has received orphan drug approval by the Food and Drug Administration (FDA) for the treatment of symptomatic neurogenic orthostatic hypotension in individuals with primary autonomic failure. The half-life of droxidopa is approximately 2-3 hours, resulting in administration three times daily.

Attention Deficit Hyperactivity Disorder

Chelsea Therapeutics20 participantsStarted Oct 2009

New York, New York, United States

COMPLETEDPhase 2< 1 mile

Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)

NCT05401565

This study will evaluate the efficacy and safety of 10 mg of oral administration balovaptan once a day (QD) compared with matching placebo in adults with PTSD.

Stress Disorders, Post-Traumatic

Hoffmann-La Roche29 participantsStarted Aug 2022

Phoenix, Arizona, United States • Bellflower, California, United States • Panorama City, California, United States +12 more locations

Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)

Rheumatoid Arthritis Trials in Other Cities

Impact of Prisma on Donor Site Pain

Treatment of Peripheral Arterial Hemorrhage With Lava LES (The LAVA Study)

Early Feeding After Oral Cavity Reconstruction

Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma

Visceral Manifold Study for the Repair of Thoracoabdominal Aortic Aneurysms

OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate

An Observational Study to Learn More About the Use of Androgen Receptor Inhibitors and How They Affect Men With Nonmetastatic Prostate Cancer in Routine Medical Care in the United States

Real-World Data Study to Understand Participant Treatment Outcomes for Dupuytren's Contracture

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study

Addressing Sleep Apnea Post-Stroke/TIA

Laser Ablation After Stereotactic Radiosurgery

Laser Ablation in Stereotactic Neurosurgery (LAISE): NeuroBlate® Retrospective Registry

The Pristine Post-Market Study

Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology

Safety, Tolerability, and Pharmacokinetics of UX053 in Patients With Glycogen Storage Disease Type III (GSD III)

Expanded Access Protocol: Repeated Administration of Nurown® (Autologous MSC-NTF Cells) for the Treatment of ALS

The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract

Study to Evaluate the Safety and Pharmacokinetics of Efmarodocokin Alfa in Combination With Standard of Care in Participants Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Other Conditions in New York