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Rheumatoid Arthritis Clinical Trials in Chicago | 3,890 Studies | Clareo Health

Clinical Trials Rheumatoid ArthritisChicago

Rheumatoid Arthritis Clinical Trials in Chicago

Find 3,890 clinical trials for rheumatoid arthritis near Chicago, Illinois. Connect with research centers in your area.

All Rheumatoid Arthritis trials nationwide All trials in Chicago

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Showing 1461-1480 of 3,890 trials

COMPLETEDPhase 22.2 miles

ET-01 in Subjects With Lateral Canthal Lines, LCL-210

NCT04985916

This study tests an investigational drug formulation called ET-01, botulinum toxin, Type A, topical, in lateral canthal lines (LCL).

Lateral Canthal Lines, LCLCrow's Feet

Eirion Therapeutics Inc.280 participantsStarted Jul 2021

Scottsdale, Arizona, United States • San Diego, California, United States • Aventura, Florida, United States +16 more locations

TERMINATEDPhase 32.2 miles

A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)

NCT04944784

The purpose of this study is to assess the effect of reldesemtiv versus placebo on functional outcomes in ALS.

Amyotrophic Lateral Sclerosis

Cytokinetics489 participantsStarted Aug 2021

Phoenix, Arizona, United States • Los Angeles, California, United States • Orange, California, United States +81 more locations

Rheumatoid Arthritis Trials in Other Cities

New York Los Angeles Houston Phoenix Philadelphia San Antonio

Data from ClinicalTrials.govTerms

COMPLETEDNA2.2 miles

Assessing Visual Feedback of HR Monitoring in Rehabilitation - Pilot

NCT05273801

Monitoring heart rate during exercise can provide feedback to the patient and provider that the patient is exercising in the appropriate, individualized and safe range for them. This is particularly important in a group setting when multiple individuals are supervised by one provider. This study is interested in assessing the difference in intensity of care delivered when visual feedback of heart rate is provided compared to no visual feedback of heart rate in rehabilitation. Visual feedback of heart rate will be provided through Heart Zones, a platform which synthesizes multiple signals from externally worn heart rate monitors. This study is interested in better understanding the acceptability, feasibility and appropriateness of this technology when used in rehabilitation.

Exercise TherapyHeart Rate Determination

Shirley Ryan AbilityLab18 participantsStarted Jan 2022

Chicago, Illinois, United States

COMPLETEDEARLY Phase 12.2 miles

Dilution of Verapamil During Intraarterial Administration

NCT05625503

This study will be a randomized, single-blind, prospective trial designed to evaluate the efficacy and safety of intra-arterial (IA) Verapamil diluted with normal saline compared to undiluted IA Nicardipine during transradial access (TRA) for percutaneous coronary angiography. Patients who are 18 years or older and undergoing non-emergent percutaneous coronary angiography via TRA will be included. Patients who are non-English speaking, pregnant, or intubated will be excluded. Patients will be randomized to one of the two following groups: 1. Group 1 will receive IA Verapamil 5 mg (2mL) diluted with 8 mL of normal saline 2. Group 2 will receive IA Nicardipine 400 mcg (undiluted, 8 mL) The investigators will document the patient's level of discomfort on the Visual Analogue Scale 30 seconds before and after administration of IA Verapamil/Nicardipine. The investigators will also document the presence of radial artery spasms.

Vasospasm;PeripheralBurningPain

University of Illinois at Chicago55 participantsStarted Dec 2022

Chicago, Illinois, United States

TERMINATEDPhase 32.2 miles

Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

NCT02864953

The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to determine if BIIB093 improves overall survival at Day 90 when compared with placebo, if BIIB093 improves functional outcome at Day 90 on the mRS dichotomized 0-4 vs. 5-6 when compared with placebo, if BIIB093 reduces midline shift at 72 hours (or at time of decompressive craniectomy \[DC\] or comfort measures only \[CMO\], if earlier) when compared with placebo, and to evaluate the safety and tolerability of BIIB093 in participants with LHI. The objectives of Part 2 of the study are to evaluate long-term disability following LHI, to evaluate long-term outcome measures of clinical function, quality of life, and healthcare utilization, and to assess the safety of BIIB093 in subjects with LHI during the follow-up period.

Brain EdemaStroke, Acute

Remedy Pharmaceuticals, Inc.535 participantsStarted Aug 2018

Phoenix, Arizona, United States • Tucson, Arizona, United States • Palo Alto, California, United States +247 more locations

Enrolling By InvitationNA12 miles

Fundoplication in Laparoscopic PEH Repair Based on FLIP

NCT05807763

Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.

Paraesophageal Hernia

The Foundation for Surgical Innovation and Education260 participantsStarted Feb 2023

Evanston, Illinois, United States • Portland, Oregon, United States

RECRUITINGPhase 1/259 miles

Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC

NCT06681688

This is a multicenter, 2-arm, randomized, prospective study of patients slated for bilateral cataract extraction. One eye will be randomized to the Study Arm, and the fellow eye will be randomized to the Control Arm.

Inder Paul Singh, M.D.94 participantsStarted Jul 2024

Venice, Florida, United States • Racine, Wisconsin, United States

COMPLETED81 miles

SpineJack System Postmarket Registry

NCT04795765

This postmarket registry is intended to prospectively collect real world data to support ongoing safety and performance of the SpineJack system.

Osteoporotic Vertebral Compression Fractures

Stryker Instruments261 participantsStarted Aug 2019

Encinitas, California, United States • Larkspur, California, United States • Stuart, Florida, United States +9 more locations

RECRUITINGPhase 381 miles

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

NCT03588975

The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of patients aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the knee.

Chondral DefectOsteochondritis Dissecans (OCD)Articular Cartilage Defect+1 more

Vericel Corporation45 participantsStarted Oct 2018

Palo Alto, California, United States • Sacramento, California, United States • Sacramento, California, United States +9 more locations

COMPLETEDPhase 4109 miles

Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Older Adult Subjects With Overactive Bladder (OAB)

NCT02216214

The purpose of this study was to assess the efficacy, safety and tolerability of mirabegron versus placebo in the treatment of older adult subjects with OAB.

Overactive Bladder (OAB)

Astellas Pharma Global Development, Inc.888 participantsStarted Oct 2014

Huntsville, Alabama, United States • Mobile, Alabama, United States • Anchorage, Alaska, United States +117 more locations

COMPLETEDNA122 miles

Pragmatic Trial Examining Oxygenation Prior to Intubation

NCT05267652

Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States. One-in-ten emergency tracheal intubations is complicated by life-threatening hypoxemia. Administering supplemental oxygen prior to induction and intubation ("preoxygenation") decreases the risk of life-threatening hypoxemia. In current clinical practice, the most common methods for preoxygenation are non-invasive positive pressure ventilation and facemask oxygen. Prior trials comparing non-invasive positive pressure ventilation and facemask oxygen for preoxygenation have been small and have yielded conflicting results. A better understanding of the comparative effectiveness of these two common, standard-of-care approaches to preoxygenation could improve the care clinicians deliver and patient outcomes.

Acute Respiratory Failure

Vanderbilt University Medical Center1,301 participantsStarted Mar 2022

Birmingham, Alabama, United States • Aurora, Colorado, United States • Iowa City, Iowa, United States +13 more locations

COMPLETED122 miles

Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA

NCT04166149

Donor-derived cell-free DNA (dd-cfDNA) has shown promise as an early marker for cellular injury caused by rejection. dd-cfDNA changes may also indicate other injuries that lead to progressive decline in transplant organ function associated with, in the case of kidney transplantation, the presence of interstitial fibrosis (IF) and tubular atrophy (TA) seen in biopsy specimens. Here, we will study the utility of dd-cfDNA to predict rejection in pancreas and pancreas-kidney recipients.

Transplant;Failure,KidneyTransplant; Failure, PancreasRejection Acute Renal+1 more

University of Maryland, Baltimore140 participantsStarted Sep 2019

Washington D.C., District of Columbia, United States • Baltimore, Maryland, United States • Madison, Wisconsin, United States

COMPLETEDPhase 1202 miles

Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid Tumors

NCT02143401

This phase I trial studies the side effects and the best dose of navitoclax when given together with sorafenib tosylate in treating patients with solid tumors that have returned (relapsed) or do not respond to treatment (refractory). Navitoclax and sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

CirrhosisHepatitis B InfectionHepatitis C Infection+6 more

National Cancer Institute (NCI)29 participantsStarted Jan 2015

Scottsdale, Arizona, United States • Sacramento, California, United States • Aurora, Colorado, United States +7 more locations

TERMINATEDPhase 3262 miles

Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery

NCT06128369

The goal of this clinical trial is to evaluate the efficacy and safety of OCS-01 in treating inflammation and pain in subjects following cataract surgery.

Inflammation EyePain, PostoperativeCataract

Oculis117 participantsStarted Dec 2023

Inglewood, California, United States • Morrow, Georgia, United States • Louisville, Kentucky, United States +9 more locations

Active Not Recruiting262 miles

MIRACLE of LIFE Study

NCT06074601

The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1. Can cell-free RNA-based biomarkers predict which pregnant people are at greatest risk of developing adverse pregnancy outcomes (e.g., preterm birth, preeclampsia)? 2. What is the performance of such biomarkers when predicting an adverse pregnancy outcome (e.g., sensitivity, specificity, PPV, NPV, TPR)?

Preterm LaborPreterm BirthPreterm Birth Complication+7 more

Mirvie10,000 participantsStarted Aug 2021

San Diego, California, United States • Orlando, Florida, United States • New Orleans, Louisiana, United States +7 more locations

COMPLETEDPhase 4262 miles

RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)

NCT05531591

The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function.

DepressionDementiaMild Cognitive Impairment+5 more

Centre for Addiction and Mental Health87 participantsStarted Aug 2019

Los Angeles, California, United States • St Louis, Missouri, United States • New York, New York, United States +1 more locations

COMPLETEDPhase 2276 miles

Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants

NCT05004181

This trial consisted of three parts, Part A, Part B, and Part C, and evaluated the safety and immunogenicity of a third (booster) injection of the multivalent vaccine BNT162b2 (B.1.1.7 + B.1.617.2), and the safety and immunogenicity of a third booster injection of the monovalent vaccine BNT162b2 (B.1.617.2) or BNT162b2 (B.1.1.7), in participants who had received two doses of the parent vaccine BNT162b2 at 30 µg, at least 6 months after the second dose of BNT162b2. It also evaluated the safety and immunogenicity of a three-dose regimen of BNT162b2 (B.1.1.7 + B.1.617.2) in participants who had not received prior Coronavirus Disease 2019 (COVID-19) vaccination. In addition, the safety and immunogenicity of BNT162b2 (B.1.1.529.1) or BNT162b2 given as a third or fourth vaccine dose to RNA COVID-19 vaccine-experienced participants with history of SARS-CoV-2 Omicron variant infection was evaluated and contrasted with the natural immune response reached after infection with the SARS-CoV-2 Omicron variant in RNA COVID-19 vaccine-experienced participants.

SARS-CoV-2 InfectionCOVID-19SARS-CoV-2 Acute Respiratory Disease+1 more

BioNTech SE1,380 participantsStarted Aug 2021

Long Beach, California, United States • San Diego, California, United States • Milford, Connecticut, United States +32 more locations

COMPLETEDNA346 miles

Audio Distraction for Traction Pin Placement

NCT05927480

Traction pin placement is a common way to temporarily manage femur fractures and unstable acetabular fractures while awaiting surgery. Skeletal traction is thought to reduce patient discomfort by improving fracture alignment as well as relaxing muscle spasm pain felt from the broken bone by stretching out the leg. Skeletal traction may also help prevent articular surface damage in the hip by decreasing joint pressure. Despite the benefits of skeletal traction, insertion of the traction pin can be a painful and unpleasant experience for the patient. Our study hopes to see if listening to music with headphones during insertion of the traction pin decrease patient pain and anxiety.

Lower Extremity Fracture

HealthPartners Institute54 participantsStarted Apr 2018

Miami, Florida, United States • Saint Paul, Minnesota, United States

Active Not RecruitingPhase 1/2355 miles

A Gene Transfer Study for Late-Onset Pompe Disease (RESOLUTE)

NCT04093349

The purpose of this study is to evaluate the safety, tolerability, and efficacy of a single intravenous infusion of SPK-3006 in adults with clinically moderate, late-onset Pompe disease receiving enzyme replacement therapy (ERT). Participants will be treated in sequential, dose-level cohorts.

Pompe DiseasePompe Disease (Late-onset)Glycogen Storage Disease Type 2+4 more

Spark Therapeutics, Inc.4 participantsStarted Oct 2020

Phoenix, Arizona, United States • Orange, California, United States • Atlanta, Georgia, United States +26 more locations

SUSPENDED667 miles

Observational Study to Assess Migraine Prediction Tool

NCT05523310

This is a prospective, observational study. The participant will be required to approve his/her participation in the study by completing the electronic consent form. Data collected within the first eight weeks (weeks 1-8) will be used to develop the prediction models (either personal or population/group models). The developed algorithm will be freezer and tested against the data collected during weeks 1-8 of a different cohort population

Theranica200 participantsStarted Jan 2030

Westport, Connecticut, United States • Ridgeland, Mississippi, United States • Poughkeepsie, New York, United States

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