Psoriasis Clinical Trials

Showing 981-1000 of 1,026 trials

Study of BMS-587101 in Patients With Moderate to Severe Psoriasis

NCT00162253

The purpose of this clinical research study is to learn if BMS-587101 is effective on the treatment of Moderate to Severe Psoriasis. The safety of this treatment will also be studied.

Psoriasis, Moderate to Severe

Bristol-Myers Squibb120 participantsStarted Apr 2005

Phoenix, Arizona, United States • Tucson, Arizona, United States • San Diego, California, United States +13 more locations

COMPLETEDPhase 4

Dose Ranging Study to Assess the Efficacy and Safety of Acitretin in Severe Plaque Type Psoriasis

NCT01039142

In this study, the investigators will intend to compare the efficacy and safety of various doses of acitretin in a randomized double blind manner in patients with severe plaque-type psoriasis, by i) studying the change PASI score from baseline as a measure of efficacy ii) determining the frequency of side effects at various doses. Sixty patients will be recruited from Psoriasis Clinic of Department of Dermatology, Venerology and Leprology, PGIMER. Patients will be randomly assigned to one of the three groups: Group A, consisting of 20 patients, will be administered acitretin 25 mg/ day ,Group B, consisting of 20 patients, will be administered acitretin 35 mg/day and GROUP C consisting of 20 patients, will be administered acitretin 50 mg/day This therapy will be continued until PSORIASIS AREA AND SEVERITY INDEX (PASI) scores are reduced to \< 25% of the original scores or 12 weeks, whichever comes earlier. It is expected that acitretin at higher doses will be more efficacious . As the exact etiopathogenesis of psoriasis is not fully known, it is difficult to provide a definite cure to all patients, though the disease activity can be controlled to a great extent with various treatment modalities. However the dosage of acitretin be adjusted according to response of the patients and tolerability of side effects.

Psoriasis

Post Graduate Institute of Medical Education and Research, Chandigarh61 participantsStarted Mar 2008

Chandigarh, Chandigarh, India

Study of BMS-587101 in Patients With Moderate to Severe Psoriasis

Dose Ranging Study to Assess the Efficacy and Safety of Acitretin in Severe Plaque Type Psoriasis

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