Melanoma Clinical Trials in Philadelphia

Showing 241-260 of 326 trials

Safety and Efficacy of Marqibo in Metastatic Malignant Uveal Melanoma

NCT00506142

Marqibo (liposomal vincristine) is a form of vincristine preparation. Vincristine is designed to interfere with the multiplication of cancer cells, which may slow or stop their growing and spreading throughout the body. This may cause the cancer cells to die. Liposomal vincristine is formed when vincristine is placed inside of oil droplets called liposomes, which may help to improve the delivery of drug to the tumor site. The liposomal formulation results in a slow, steady release of vincristine in the tumor metastasis, exposing the cancer cells to vincristine continuously. The goal of this clinical research study is to learn if Marqibo (liposomal vincristine) can help to control metastatic uveal melanoma. The safety of liposomal vincristine will also be studied. Approximately 50 patients will take part in this study.

Metastatic Malignant Uveal Melanoma

Spectrum Pharmaceuticals, Inc54 participantsStarted Nov 2007

Los Angeles, California, United States • Denver, Colorado, United States • Philadelphia, Pennsylvania, United States +1 more locations

COMPLETEDPhase 2< 1 mile

Vorinostat in Treating Patients With Metastatic or Unresectable Melanoma

NCT00121225

This phase II trial is studying how well vorinostat works in treating patients with metastatic or unresectable melanoma. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Ciliary Body and Choroid Melanoma, Medium/Large SizeExtraocular Extension MelanomaIris Melanoma+4 more

National Cancer Institute (NCI)32 participantsStarted Sep 2005

Philadelphia, Pennsylvania, United States • Rockledge, Pennsylvania, United States • Hamilton, Ontario, Canada +2 more locations

Safety and Efficacy of Marqibo in Metastatic Malignant Uveal Melanoma

Vorinostat in Treating Patients With Metastatic or Unresectable Melanoma

Melanoma Trials in Other Cities

LC Bead Embolization Agent With Doxorubicin in the Treatment Liver Metastasis From Melanoma

The Skin Savvy Study: A Behavioral Skin Cancer Prevention Intervention

A Study of CDX-1127 (Varlilumab) in Patients With Select Solid Tumor Types or Hematologic Cancers

Safety Study of PLX4032 in Patients With Solid Tumors

PROCLAIM Registry to Evaluate the Treatment Patterns and Clinical Response in Malignancy

A Study of Tasisulam-sodium Versus Paclitaxel as Treatment for Metastatic Melanoma

Bevacizumab and Temozolomide or Bevacizumab and Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed by Surgery

Single-arm Trial to Evaluate the Biodistribution and Shedding of Talimogene Laherparepvec

A Study of Intratumoral CAVATAK™ in Patients With Stage IIIc and Stage IV Malignant Melanoma (VLA-007 CALM )

Phase II Trial of Pimasertib Versus Dacarbazine in N-Ras Mutated Cutaneous Melanoma

Nilotinib in TKI Resistant or Intolerant Patients With Metastatic Mucosal, Acral, or Chronically Sun Damaged Melanoma

Phase II Safety Study of Vemurafenib Followed by Ipilimumab in Subjects With V600 BRAF Mutated Advanced Melanoma

Trial of Vemurafenib/Cobimetinib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanoma

Study to Evaluate Treatment of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain

A Study of Tasisulam in Treating Participants With Malignant Melanoma

Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone

A Study of Vemurafenib in Participants With Metastatic Melanoma

A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State

Other Conditions in Philadelphia