Lupus Clinical Trials

Showing 2041-2060 of 2,686 trials

Potential Mechanism of Exercise Impairment in OSA

NCT02505594

Obstructive sleep apnea (OSA) is a common disorder with major cardiovascular sequelae. A recent study confirmed that OSA is associated with impaired exercise capacity and increasing OSA severity predicts worsening exercise capacity, which is a marker of potential increased cardiovascular risk. However, potential mechanisms of decreased exercise capacity caused by OSA remain unclear. Several pathophysiologic mechanisms of OSA have been proposed and investigators hypothesize that endothelial dysfunction leading to exercise-induced right ventricular dysfunction and associated pulmonary hypertension is the potential mechanism for impaired exercise capacity in OSA.

Obstructive Sleep Apnea

University of California, San Diego29 participantsStarted Jul 2015

San Diego, California, United States

COMPLETEDPhase 2

Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus

NCT01972568

This is a multi-center, double-blind, randomized, Phase 2b trial to evaluate the efficacy of atacicept in subjects with systemic lupus erythematosus (SLE).

Lupus Erythematosus, Systemic

EMD Serono306 participantsStarted Dec 2013

Anniston, Alabama, United States • Birmingham, Alabama, United States • Birmingham, Alabama, United States +135 more locations

Potential Mechanism of Exercise Impairment in OSA

Efficacy and Safety of Atacicept in Systemic Lupus Erythematosus

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