Leukemia Clinical Trials

Showing 681-700 of 10,987 trials

Enfortumab Vedotin Schedule De-escalation in Metastatic Urothelial Carcinoma

NCT05923190

This is a non-randomized two arm open-label phase 2 pilot study in adult subjects with locally advanced or metastatic urothelial cancer. The study will investigate an alternative administration schedule of EV given as monotherapy and in combination with pembrolizumab.

Urothelial CarcinomaMetastatic Urothelial CarcinomaLocally Advanced Urothelial Carcinoma

Fox Chase Cancer Center60 participantsStarted Jun 2023

Philadelphia, Pennsylvania, United States

RECRUITINGPhase 2

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

NCT06406114

Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in allergic patients is based on side chain chemical similarity and limited skin testing evidence. This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics.

Drug AllergyCephalosporin AllergyDrug Hypersensitivity+4 more

Massachusetts General Hospital300 participantsStarted May 2025

Scottsdale, Arizona, United States • San Francisco, California, United States • Boston, Massachusetts, United States +3 more locations

Enfortumab Vedotin Schedule De-escalation in Metastatic Urothelial Carcinoma

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

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