Leukemia Clinical Trials

Showing 4741-4760 of 10,987 trials

Comorbidity Burden and Use of Concomitant Medications at CML Diagnosis

NCT06042660

The aim of the retrospective study was to further characterize the prevalence of comorbid conditions as well as the use of concomitant medications in newly diagnosed CML patients in a real-world setting. Hematologists from ten Polish hematological tertiary care centers were asked to analyze medical records for all consecutive CML patients diagnosed with chronic phase CML between January 1st 2005 and December 31st 2014.

Chronic Myeloid Leukemia

Polish Adult Leukemia Group527 participantsStarted Feb 2016

WITHDRAWNPhase 2

Niraparib for the Treatment of Leiomyosarcoma

NCT05174455

This phase II trial tests whether niraparib works to shrink tumor in patients with leiomyosarcoma. Niraparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.

Locally Advanced LeiomyosarcomaMetastatic LeiomyosarcomaStage III Retroperitoneal Sarcoma AJCC v8+4 more

David Liebner, MDStarted Dec 2023

COMPLETEDNA

Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

NCT02336282

A common and potentially debilitating late effect of childhood cancer treatment is neurocognitive impairment, frequently in the domain of executive dysfunction, which can limit educational attainment, employment, and quality of life. Among the survivors of childhood acute lymphoblastic leukemia (ALL) in the SJLIFE cohort, the frequency of executive function impairment has been shown as high as 58.8%, with moderate to severe impairment as high as 33.5%, and risk for impairment increased with time from diagnosis. Given the potential of pervasive impact of neurocognitive impairment on daily life, interventions directed at reducing neurocognitive dysfunction among childhood cancer survivors with long-term follow-up are needed. This study examines the potential feasibility and efficacy of a novel intervention to improve executive function. Primary Objectives: * To evaluate the feasibility of a home-based intervention using Transcranial Direct Current Stimulation (tDCS) and cognitive training in adult survivors of childhood ALL participating in the SJLIFE protocol at St. Jude Children's Research Hospital (SJCRH). Secondary Objectives: * To estimate the efficacy of a tDCS intervention paired with cognitive training. * To explore the short-term effect of tDCS on measures of executive function among adult survivors of childhood ALL participating in the SJLIFE protocol

Acute Lymphoblastic Leukemia

St. Jude Children's Research Hospital53 participantsStarted Jan 2015

Memphis, Tennessee, United States

Comorbidity Burden and Use of Concomitant Medications at CML Diagnosis

Niraparib for the Treatment of Leiomyosarcoma

Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

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