Leukemia Clinical Trials

Showing 4061-4080 of 10,987 trials

Benadamustine, Fludarabine and Busulfan Conditioning in Recipients of Haploidentical Stem Cell Transplantation (FluBuBe)

NCT04942730

Haploidentical hematopoietic stem cell transplantation irrespective of the conditioning and graft-versus-host disease prophylaxis is associated with high frequency of primary and secondary graft failure. Different technologies of with replete or depleted graft are associated with 10-20% of graft failures. Fludarabine and busulfan conditioning is the most commonly used approach for a variety of disease. Furthermore combination of fludarabine and bendamustine was sufficient to facilitate engraftment in patients with chronic lymphocytic leukemia and lymphomas. The aim of the study is to evaluate whether addition of bendamustine to fladarabine and busulfan conditioning reduces the risk of primary graft failure after haploidentical allograft.

Leukemia, Acute LymphoblasticMyeloid Leukemia, AcuteBiphenotypic Acute Leukemia+3 more

St. Petersburg State Pavlov Medical University50 participantsStarted Jan 2021

Saint Petersburg, Russia

RECRUITINGPhase 2

Consolidation Serplulimab Following Concurrent Chemoradiotherapy for LS-SCLC Patients

NCT05443646

This study is a multi-center, Single-arm Phase II study to evaluate the clinical efficacy and safety of Consolidation HLX10 (Serplulimab) Following Hypofractionated Radiotherapy With Concurrent Chemotherapy for Patients With Limited Stage Small Cell Lung Cancer

Limited Stage Small Cell Lung Cancer

Cancer Institute and Hospital, Chinese Academy of Medical Sciences55 participantsStarted Sep 2022

Jiamusi, Heilongjiang, China • Taiyuan, Shanxi, China

Benadamustine, Fludarabine and Busulfan Conditioning in Recipients of Haploidentical Stem Cell Transplantation (FluBuBe)

Consolidation Serplulimab Following Concurrent Chemoradiotherapy for LS-SCLC Patients

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