Leukemia Clinical Trials

Showing 3721-3740 of 10,987 trials

Guadecitabine Extension Study

NCT03603964

This is a multicenter, open-label extension study for participants who participated in a previous Astex-sponsored guadecitabine clinical study \[including but not limited to SGI-110-01 (NCT01261312), SGI-110-04 (NCT02348489), SGI-110-06 (NCT02920008), and SGI-110-07 (NCT02907359)\].

Acute Myeloid LeukemiaMyeloid Dysplastic Syndrome

Astex Pharmaceuticals, Inc.35 participantsStarted Jul 2018

Buffalo, New York, United States • Durham, North Carolina, United States • Columbus, Ohio, United States +18 more locations

COMPLETEDPhase 2

Guadecitabine With or Without Idarubicin or Cladribine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

NCT02096055

This randomized phase II trial studies how well guadecitabine with or without idarubicin or cladribine works in treating older patients with previously untreated acute myeloid leukemia. Guadecitabine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as idarubicin and cladribine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether guadecitabine with or without idarubicin or cladribine is more effective in treating older patients with previously untreated acute myeloid leukemia.

Untreated Adult Acute Myeloid Leukemia

M.D. Anderson Cancer Center44 participantsStarted Apr 2014

Houston, Texas, United States

Guadecitabine Extension Study

Guadecitabine With or Without Idarubicin or Cladribine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

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