Leukemia Clinical Trials

Showing 2121-2140 of 10,987 trials

Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders

NCT00267501

The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of, clinical manifestations of, and spectrum of disease severity of eosinophilic inflammation in humans.

Eosinophilic Gastrointestinal Disease Eosinophilic Inflammatory DiseaseFood Allergy

Children's Hospital Medical Center, Cincinnati5,000 participantsStarted May 2005

Cincinnati, Ohio, United States

RECRUITINGPhase 1/2

Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

NCT06567015

The goal of this First-In-Human (FIH) Phase I/II trial is to establish the safety profile, determine the Recommended Phase II Dose (RP2D), explore the pharmacokinetic (PK) exposure and pharmacodynamic (PD) properties as well as assess the efficacy of STX-241/PFL-241, a mutant selective Central Nervous System (CNS)-penetrant fourth generation EGFR TKI, in participants with locally advanced or metastatic NSCLC that progressed during or following third generation EGFR TKI such as osimertinib due to C797X double acquired (secondary) mutations.

Non-small Cell Lung Cancer (NSCLC)

Pierre Fabre Medicament171 participantsStarted Sep 2024

Nashville, Tennessee, United States • Houston, Texas, United States • Shanghai, China +13 more locations

Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders

Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

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