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Browse 3,518 clinical trials for hypertension. Find studies that match your criteria and connect with research centers.
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NCT04994119
The purpose of this study is: * To investigate CYP2C9 inhibition by BIA 5-1058 through the assessment of its effect on the Pharmacokinetic (PK) of S-warfarin, a substrate of CYP2C9. * To assess the effect of warfarin on the PK of BIA 5-1058.
NCT04991207
the purpose of this study is: * To assess the effect of BIA 5 1058 400 mg on the PK of bosentan. * To assess the effect of bosentan on the PK of BIA 5 1058
NCT04975490
This single-center prospective observational study aims at characterization of pathogenesis of ACLF. There will be three different cohorts investigated with the main endpoint mortality in these groups. 1. SAPIENT = Sepsis ACLF patients, to investigate the differences between ACLF and sepsis in cirrhosis 2. PROACT = Portal mediators as ACLF Targets, to assess portal venous biomarkers in patients receiving TIPS leading to ACLF and identify potential treatment targets 3. ELITE = prEdictors of beneficial LIver Tx in ACFL patiEnts, to assess in ACLF-patients receiving liver transplantation predictors of survival, which may improve selection of ACLF-patients for liver transplantation Secondary endpoints will be different in the three different cohorts and biological material will be collected for separate ancillary studies.