Hypertension Clinical Trials

Showing 881-900 of 1,710 trials

Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease

NCT04361097

What the investigators want to achieve with the protocol is to identify the impact of intestinal microbiota transplantation on the progression of chronic kidney disease. Hypothesis: Modification of intestinal microbioma of CKD patients by TMF decrease the progression of CKD Methodological design: Experimental, prospective, double-blind. Inclusion criteria: Being diagnosed with CKD and creatinine clearance less than 60 mL/minute secondary hypertension and/or diabetes and older than 18 years

Chronic Kidney Disease Due to HypertensionChronic Kidney Disease Due to Type 2 Diabetes Mellitus

Hospital Universitario Dr. Jose E. Gonzalez28 participantsStarted Aug 2018

Monterrey, Nuevo León, Mexico

COMPLETEDPHASE2

A Dose-escalation Study in Subjects With Pulmonary Arterial Hypertension (PAH)

NCT03177603

GSK2586881, a purified intravenous (IV) formulation of soluble recombinant human Angiotensin Converting Enzyme (rhACE2) is being investigated as a treatment for PAH. This GlaxoSmithKline (GSK) study will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of GSK2586881 in subjects with PAH. This open-label, dose-escalation study will comprise of 4 separate groups based on the planned dose range, and subjects in each group will be administered a single dose of GSK2586881 ranging between 0.1, 0.2, 0.4 and 0.8 milligram per kilogram (mg/kg) via IV route. Dose escalation will occur after 4 subjects have been dosed per cohort and review of safety, tolerability, PK and hemodynamic data up to 24 hours post dose has taken place. A maximum of 27 subjects will be included in the study and the total duration of the study will be up to a maximum of 59 days.

Hypertension, Pulmonary

GlaxoSmithKline23 participantsStarted Feb 2018

Pittsburgh, Pennsylvania, United States • Dallas, Texas, United States • Heidelberg, Baden-Wurttemberg, Germany +5 more locations

Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease

A Dose-escalation Study in Subjects With Pulmonary Arterial Hypertension (PAH)

Related Searches

Renin-Angiotensin System Inhibitors and COVID-19

Effectiveness of a Natural Ingredient on Obesity

Using Health-related Quality of Life (HRQL) in Routine Clinical Care

Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension

A Targeted and Tailored Pharmacist Intervention to Improve Adherence to Antihypertensive Drugs Among Diabetes Patients

ActiV.A.C.+ Compression Therapy Versus Compression Therapy Alone for the Treatment of Chronic Venous Ulcerations

Invasive Versus Non-invasive Assessment of Blood Pressure in Hypertensive Disorders of Pregnancy

"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"

Blood Pressure Control in ESH Excellence Centres

Hypotonic Treprostinil Subcutaneous Infusion for Control of Treprostinil Related Site Pain

Approaches to Reduce Clinical Inertia in Hypertension in the Dominican Republic

The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose

Renal Denervation in Treatment Resistant Hypertension

Treatment of Moderate and Severe Cirrhotic Portal Hypertension Due to HBV With Fuzheng Huayu and Entecavir

Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAH

Comparative Effects of Perindopril and Zofenopril on Blood Pressure Control and Oxidative Status Blacks Hypertensive Patients.

Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of CKD-333 in Healthy Volunteers

Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype