HIV/AIDS Clinical Trials

Showing 61-80 of 1,802 trials

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

NCT05136703

The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.

DepressionHIV-1-infectionInflammation

Florida International University150 participantsStarted Aug 2022

Coral Gables, Florida, United States • Miami, Florida, United States

COMPLETEDPHASE1

A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Two Different Formulations of Long-acting Cabotegravir in Healthy Adult Participants

NCT06033547

The primary purpose of the study is to investigate the safety, tolerability, and pharmacokinetic (PK) profiles of two different cabotegravir formulations in healthy adult participants. The study will initially start with the assessment of Cabotegravir Formulation F. Once the clinical batch of Cabotegravir Formulation G is available, this formulation will be assessed.

HIV Infections

ViiV Healthcare56 participantsStarted Sep 2023

Austin, Texas, United States

ACTIVE_NOT_RECRUITINGNA

Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe

NCT06226155

The purpose of this study is to develop a multi-level PrEP adherence and persistence intervention as an adaptation of the TENDAI ('grateful' in Shona) program, a problem-solving approach to reduce depression and increase HIV treatment adherence among people living with HIV in Zimbabwe. The new intervention, TENDAI4PrEP, will be designed to improve PrEP uptake and persistence among pregnant persons in Zimbabwe. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to address a critical public health challenge impacting pregnant and postpartum persons in Zimbabwe: the prevention of HIV acquisition and transmission.

HIV InfectionsPregnancy RelatedDepression, Anxiety

Massachusetts General Hospital132 participantsStarted Oct 2024

Harare, Zimbabwe

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Two Different Formulations of Long-acting Cabotegravir in Healthy Adult Participants

Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe

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Safety Study of MucoCept-CVN

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Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

Long-Acting Injectable HIV PrEP PROs

Evaluating Safety and Immune Response to the HIV-1 CH505 Transmitted/Founder gp120 Adjuvanted With GLA-SE in Healthy, HIV-exposed Uninfected Infants

Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients

The Impact of Brief Behavioral Treatment for Insomnia Versus Brief Mindfulness Treatment on Cognition and Sleep Health in Adults (Age 50+) With HIV

Multiplo Tp/HIV Self-Test

Wellness, Intervention Strategies and HIV Care

Evaluating an Algorithm-Based Implementation Strategy to Improve HIV Care Outcomes

Developing and Testing a Digital Health Tool for INterseCtional Stigma Assessment and Reduction at Multiple Levels and mUltiple DimEnsions (INCLUDE) to Improve HIV Care in ART Centers in Nepal