Diabetes Clinical Trials

Showing 1921-1940 of 7,874 trials

Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus.

NCT03380546

Caring for women with gestational diabetes mellitus (GDM) is very time-consuming. Therapeutic strategy includes dietary and lifestyle measures and additional insulin therapy for 15 to 40% of the women with GDM if the glycemic targets are not achieved after a period of 1 to 2 weeks of diet. Insulin therapy is imperfect for the following main reasons: need for education (i.e. subcutaneous administration, dose titration), hypoglycemia and weight gain, limited acceptance and high cost. Psychosocial deprivation is associated with more cases of GDM and health accessibility may be unequal. Glucosidase inhibitors (acarbose) reduce intestinal absorption of starch and reduce the rate of complex carbohydrate digestion. It mainly lowers postprandial glucose values and is used in type 2 diabetes for a long time. Less than 2% of a dose is absorbed as active drug in adults, with 34% of the metabolites found in the systemic circulation. Doses of up to 9 and 32 times the human dose were not teratogenic in pregnant rats or rabbits. Limited but reassuring data during pregnancy are available. Acarbose was well tolerated (little gestational weight gain, no hypoglycemia) with digestive discomfort in some women, balanced by treatment satisfaction as compared with insulin injections. Our hypothesis is that treatment aiming to control postprandial glucose values with acarbose as compared with prandial insulin injection will be as efficient and safe, but more convenient and less expensive.

Gestational Diabetes Mellitus in Pregnancy

Assistance Publique - Hôpitaux de Paris341 participantsStarted Jul 2018

Bondy, France

RECRUITING

Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy

NCT05546138

Predicting early onset neuropathy in people with type 1 diabetes

Neuropathy, DiabeticSmall Nerve Fiber NeuropathyType 1 Diabetes

Aalborg University Hospital200 participantsStarted Oct 2023

Aalborg, Denmark

Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus.

Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy

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