Crohn's Disease Clinical Trials

Showing 441-460 of 1,088 trials

Therapeutic Optimization Study Based on MR Enterocolonography in Patients With Crohn's Disease

NCT02332356

This randomized, controlled study aims to evaluate the impact of therapeutic intervention (step up) for the patients who are clinical remission with Magnetic Resonance Enterocolonography (MREC) active. In addition, to evaluate the impact of therapeutic step down for the patients who archived clinical and MREC remission. The primary endpoint is the rate of clinical remission at 104 weeks.

Crohn Disease

Tokyo Medical and Dental University100 participantsStarted Sep 2014

Tokyo, Japan

UNKNOWNPhase 1

A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease

NCT04521205

There are many limitations in the current treatments of Inflammatory bowel disease(IBD). Some patients have no or little reaction to the traditional drugs. Now the investigators realized that the intestinal microbiota is closely associated with the development of IBD. In recent years, a retrospective study showed that the overall efficiency of fecal microbiota transplantation (FMT) for IBD was 79%, the overall remission rate was 43%, which opened a new chapter in the treatment of IBD. So the standardized fecal microbiota transplantation is considered to be simple but effective emerging therapies for the treatment of IBD. In this project the investigators intend to carry out a single-center, randomized, single-blind clinical intervention study. The investigators plan to recruit patients with IBD (Ulcerative Colitis and Crohn's Disease) in China. The patients will be randomly divided into two groups, one group will be given treatment of standardized fecal microbiota transplantation, the other will be simply treated with traditional drugs, followed up for at least 1 year. The investigators aim to determine the efficiency, durability and safety of Fecal Microbiota Transplantation for IBD treatment, and further to explore which major microbiota may effect in this project.

Inflammatory Bowel Disease, Ulcerative Colitis Type

Zhongshan Hospital Xiamen University200 participantsStarted Dec 2020

Xiamen, China

COMPLETEDPhase 2

Semapimod for Treatment of Moderate to Severe Crohn's Disease 1 or 3 Days' Treatment Versus Placebo

NCT00739986

Assessment of the number of days' treatment with semapimod necessary for efficacy, as measured by response rate to CNI-1493 as compared to placebo, in patients with moderate to severe Crohn's disease (CD).

Crohn's Disease

Ferring Pharmaceuticals152 participantsStarted Oct 2002

San Diego, California, United States • San Francisco, California, United States • Atlanta, Georgia, United States +25 more locations

Therapeutic Optimization Study Based on MR Enterocolonography in Patients With Crohn's Disease

A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease

Semapimod for Treatment of Moderate to Severe Crohn's Disease 1 or 3 Days' Treatment Versus Placebo

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Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study

Early Bowel Resection for Terminal Ileal Crohn's Disease

Real World Data on Vedolizumab Concentration and Outcomes in Inflammatory Bowel Disease (IBD) Patients Switching From Intravenous (IV) to Subcutaneous (SC) Vedolizumab in University Hospital Center Osijek

CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Crohn's Disease (LIBERTY-CD)

PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial

Exclusive Enteral Nutrition for Remissionof Crohn's Diseases After Surgery

Microbiome Sampling in GI Disease With a Focus on Small Intestinal Microbial Assessment

A Personalized Approach to Abdominal Pain in Irritable Bowel Syndrome

An Extension Study to Evaluate the Long-Term Safety and Tolerability of UTTR1147A in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease

Shear-Wave Elastography in Intestinal Fibrosis Evaluation in Crohn's Disease

Impact of a New Plant-based High-energy Oral Nutritional Supplement on Nutritional Outcomes in Malnourished Patients

Diet in Pediatric Crohn´s Disease Treated With Biologics

Assessment of Nutritional Status of Patients With Crohn's Disease

Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease

The MOTOR-CD Trial

Non-Invasive Monitoring Through Bowel Ultrasound in Paediatric Inflammatory Bowel Disease Study

Study of the Role of Pomegranate Juice Ellagitannins in the Modulation of Inflammation in Inflammatory Bowel Disease