Colorectal Cancer Clinical Trials in Nashville

Showing 241-260 of 361 trials

First-in-Human Study of JNJ-74699157 in Participants With Tumors Harboring the KRAS G12C Mutation

NCT04006301

The purpose of this study is to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of JNJ-74699157 in participants with advanced solid tumors harboring a kirsten rat sarcoma virus homolog (KRAS) glycine-to-cysteine (G12C) mutation (Part 1: Dose escalation) and to determine the safety and preliminary antitumor activity of JNJ-74699157 at the RP2D regimen in participants with advanced solid tumors harboring a KRAS G12C mutation (Part 2: Dose expansion).

NeoplasmsAdvanced Solid TumorsNon-small Cell Lung Cancer+1 more

Janssen Research & Development, LLC10 participantsStarted Jul 2019

Sarasota, Florida, United States • Tampa, Florida, United States • Nashville, Tennessee, United States +4 more locations

COMPLETEDPhase 2< 1 mile

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

NCT00006366

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which regimen of radiation therapy plus chemotherapy is more effective for rectal cancer. PURPOSE: Randomized phase II trial to compare two regimens of radiation therapy plus chemotherapy followed by surgery in treating patients who have locally advanced cancer of the rectum.

Colorectal Cancer

Radiation Therapy Oncology GroupStarted Feb 2001

Birmingham, Alabama, United States • Huntsville, Alabama, United States • Huntsville, Alabama, United States +232 more locations

First-in-Human Study of JNJ-74699157 in Participants With Tumors Harboring the KRAS G12C Mutation

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Colorectal Cancer Trials in Other Cities

A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in Low Anterior Resection

A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors

A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370)

TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors

A Study in Second Line Metastatic Colorectal Cancer

A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)

Blood and Stool Sample Collection in Subjects Participating in Colorectal Cancer Screening: Act Bold

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer

Cetuximab, Bevacizumab & 5FU/Leucovorin vs. Oxaliplatin, Bevacizumab & 5FU/Leucovorin in Metastatic Colorectal Cancer

Study of CS-7017 in Combination With FOLFIRI in Subjects With Metastatic Colorectal Cancer Who Failed First-Line Therapy

Observational Study of Sub-populations From Cologuard Post-Approval Study (2014-01)

Paired Analysis of Sensitivity for Colorectal Cancer Using COLVERA : PASCAL

A Study of OMP-305B83 in Subjects With Metastatic Colorectal Cancer

Sym004 vs Standard of Care in Subjects With Metastatic Colorectal Cancer

Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer

Validation of Colon Biomarkers for the Early Detection of Colorectal Adenocarcinoma

Interactive Cancer Communication System (ICCS) Directed Physical Activity Enhancement for Colon Cancer Survivors

Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening

Other Conditions in Nashville