Breast Cancer Clinical Trials

Showing 3641-3660 of 5,597 trials

Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep

NCT03420105

The results of this study will contribute to a better understanding of prospective memory deficit processes in breast cancer in relation to sleep disorders frequently reported in this pathology. In the long term, a better understanding will make it possible to envisage appropriate treatments to compensate for these memory difficulties and to improve the autonomy of the patients.

Breast CancerMemory Disorders

Centre Francois Baclesse75 participantsStarted Jan 2018

Caen, France • Caen, France

COMPLETEDPhase 1

A Phase Ib Dose De-escalation Study With BYL719 in Premenopausal Patients With Locally Advanced or Metastatic Breast Cancer

NCT02058381

Based on the evidence acquired in the post-menopausal setting with everolimus and on pre-clinical evidences supporting the investigation of PI3K inhibitors, such as alpelisib and buparlisib, in combination with endocrine therapy in hormone receptor-positive MBC, the purpose of this phase Ib trial is to assess the maximum tolerated dose (MTD) and/or the RP2D(s), to characterize the safety and tolerability, to determine the single and multiple dose PK profile and assess the preliminary anti-tumor activity of alpelisib and buparlisib in combination with tamoxifen plus goserelin acetate in premenopausal hormone receptor-positive advanced breast cancer patientsgroup.

Pre-menopausal Breast CancerPI3K Pathway Inhibition

Novartis Pharmaceuticals40 participantsStarted May 2014

Hong Kong, Hong Kong • Seongnam-si, Gyeonggi-do, South Korea • Gyeonggi-do, Korea, South Korea +12 more locations

Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep

A Phase Ib Dose De-escalation Study With BYL719 in Premenopausal Patients With Locally Advanced or Metastatic Breast Cancer

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