Brain Cancer Clinical Trials

Showing 41-60 of 1,466 trials

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

NCT06108206

The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma will help improve the radiation treatment.

GlioblastomaAnaplastic AstrocytomaAstrocytoma+1 more

Columbia University20 participantsStarted Jan 2024

New York, New York, United States

RECRUITINGNA

NK Cell Therapy for Malignant Solid Brain Tumors

NCT07552233

This is a multi-center, open-label investigator-initiated trial (IIT) designed to evaluate the safety, tolerability, and feasibility of combined intracranial and intravenous administration of ex vivo expanded and activated natural killer (NK) cells in adult patients with malignant solid brain tumors who have failed standard treatment modalities. The primary objective is to determine the maximum tolerated dose (MTD) or maximum feasible dose (MFD) of the combined NK cell therapy. Secondary objectives include preliminary assessment of anti-tumor activity as measured by progression-free survival (PFS), overall survival (OS), objective response rate (ORR) per RANO criteria, and evaluation of the immunological effects of NK cell infusion in the tumor microenvironment and peripheral blood.

Malignant Solid Brain TumorsGlioblastoma (GBM)Glioblastoma Multiforme (GBM)+2 more

Peking University Third Hospital27 participantsStarted Apr 2026

Beijing, Beijing Municipality, China • Qinhuangdao, Hebei, China • Zhengzhou, Henan, China +1 more locations

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

NK Cell Therapy for Malignant Solid Brain Tumors

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