Asthma Clinical Trials

Showing 3001-3020 of 4,312 trials

The Effect of Benralizumab on Exercise-induced Bronchoconstriction

NCT03327701

Severe asthma affects 5-10% of more than 300 million asthmatics. Ten to twenty percent of individuals suffering from asthma do not respond well to current treatment due to the complexity of the different mechanisms underlying asthma pathogenesis, and sometimes due to an insufficient effect of treatment on underlying airway inflammation. Consequently, some asthmatics have poorer quality of life due to: frequent asthma symptoms, regular medical or emergency visits, limitation in their activities of daily living, including exercise. It is believed that the benralizumab can help to reduce airway inflammation and thus improve exercise tolerance in individuals with asthma. The main objective of this study is to determine the effect of benralizumab on exercise-induced bronchoconstriction (EIB) and exercise tolerance in moderate to severe eosinophilic asthmatics, in comparison with baseline values and a placebo treatment.

Asthma, Exercise-Induced

Louis-Philippe Boulet40 participantsStarted Dec 2017

COMPLETEDNA

A Comparison of Three Nebulizers for Standard Clinical and Research Use in Methacholine Challenge Testing

NCT02822859

The study will assess three different nebulizers for use in methacholine challenge testing in order to determine if the Aeroneb Solo would make a suitable replacement for the long-used and now obsolete Wright and Bennett-Twin nebulizers. Results from each device will be compared to evaluate whether current guidelines for the methacholine challenge should be updated for superior standardization.

Asthma

University of Saskatchewan60 participantsStarted Jun 2016

Hamilton, Ontario, Canada • Saskatoon, Saskatchewan, Canada • Québec, Canada

COMPLETEDNA

Down-titration of Steroids in Patients With Difficult Asthma With no Bronchial Hyperreactivity

NCT03321877

An 8 week 'real-life' inhaled corticosteroid (ICS) dose reduction study in patients with severe asthma without evidence of bronchial hyperactivity.

Asthma

Bispebjerg Hospital9 participantsStarted Oct 2016

Copenhagen, Denmark

The Effect of Benralizumab on Exercise-induced Bronchoconstriction

A Comparison of Three Nebulizers for Standard Clinical and Research Use in Methacholine Challenge Testing

Down-titration of Steroids in Patients With Difficult Asthma With no Bronchial Hyperreactivity

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