Alzheimer's Disease Clinical Trials

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A Study of the Biodistribution and Safety of [18F]GTP1 in Healthy Japanese Participants

NCT04394845

The purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of \[18F\]GTP1 as a tau targeted radiopharmaceutical in healthy Japanese participants.

Alzheimer Disease

Genentech, Inc.6 participantsStarted Aug 2020

New Haven, Connecticut, United States

COMPLETEDPHASE3

A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection

NCT00000702

To test whether zidovudine (AZT) is useful as a treatment for the neurologic syndrome called AIDS dementia complex. To determine how long AZT takes to reach cerebral spinal fluid (CSF), how long, and at what concentration it is found there. HIV infection can result in impairment in the function of the brain and spinal cord, leading to disturbances in the ability to think clearly and in strength and coordination. This disorder, which has been called the AIDS dementia complex, may be due to a direct effect of HIV on the nervous system. It is known that AZT does get into the brain to some extent, where it may reduce growth of HIV. It is hoped that AZT will stabilize or improve the symptoms of the AIDS dementia complex.

AIDS Dementia ComplexHIV Infections

National Institute of Allergy and Infectious Diseases (NIAID)315 participants

Los Angeles, California, United States • San Diego, California, United States • Stanford, California, United States +18 more locations

A Study of the Biodistribution and Safety of [18F]GTP1 in Healthy Japanese Participants

A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection

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