Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Birjand University of Medical Sciences
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age between 18 and 65 years.
Confirmed diagnosis of Generalized Anxiety Disorder (GAD) according to DSM-5-TR and ICD-11 criteria (6B00), established through a structured clinical interview conducted by a trained clinician.
GAD must be the primary psychiatric diagnosis.
Persistent and excessive worry occurring on most days for at least six months, accompanied by associated symptoms consistent with GAD diagnostic criteria.
Baseline Hamilton Anxiety Rating Scale (HAM-A) total score of at least 7.
Generalized Anxiety Disorder 7-item scale (GAD-7) score between 5 and 14.
Perceived Stress Scale-10 (PSS-10) score of 15 or higher.
Patient Health Questionnaire-9 (PHQ-9) score of 14 or lower.
PTSD Checklist for DSM-5 (PCL-5) score below 33.
Pittsburgh Sleep Quality Index (PSQI) score below 15.
Beck Depression Inventory-II (BDI-II) score between 0 and 28.
Participants must be either treatment-free or receiving stable pharmacological treatment for at least six weeks before enrollment.
Participants receiving pharmacological treatment must agree to maintain their current medication regimen throughout the intervention period.
You may not be if
Diagnosis of post-traumatic stress disorder (PTSD), complex PTSD, social anxiety disorder, panic disorder, or specific phobia as a primary diagnosis.
Moderate-to-severe depressive symptoms, defined as a PHQ-9 score of 15 or higher.
Diagnosis of bipolar disorder or psychotic disorders.
Active suicidal ideation requiring immediate clinical intervention.
Substance use disorder within the six months preceding enrollment.
Current use of other neuromodulation therapies.
Presence of implanted electronic medical devices.
Serious or uncontrolled cardiovascular or neurological conditions.
Pregnancy or breastfeeding.
Participation in another interventional clinical study within 30 days before enrollment.
Initiation of a new medication or any change in medication dosage within six weeks before enrollment.
