PRIMARY OBJECTIVES:
I. To collect, process, and analyze blood samples from primary prostate cancer patients receiving care at the Masonic Cancer Center.
II. To collect and analyze retrospective and prospective corresponding clinical and laboratory data on disease characterization, treatment, and outcomes.
III. To explore NK cell and broad immune surface marker expressions in prostate cancer patients with diverse racial backgrounds using a 42-marker mass cytometry panel.
IV. To analyze tissue biopsy samples previously collected during the standard of care diagnostic process using multiplex immunofluorescence and spatialomics analysis.
V. To develop, produce, and conduct pre-clinical validations of a B7-H3/PSMA TriKE-PACC using in vitro and in vivo assays using de-identified normal donor blood samples.
OUTLINE: This is an observational study.
Patients undergo collection of blood samples and have their medical records reviewed on study. Patients may undergo collection of residual tissue samples, if available, on study.
